Defensamide (MHP)

For research use only.

Catalog No.S6512

Defensamide (MHP) Chemical Structure

Molecular Weight(MW): 293.36

Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.

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Biological Activity

Description Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
Targets
SPHK1 [1]
()
In vitro

Treatment with MHP directly activates SPHK1 and increases cellular S1P content in normal cultured human keratinocytes. MHP also stimulates CAMP production and enhances epidermal antimicrobial defense via the recently identified S1P-dependent mechanism[1]. Defensamide (MHP) treatment also activates NF-κB which is assessed by nuclear translocation of NF-κB[2].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (340.87 mM)
Water 100 mg/mL (340.87 mM)
Ethanol Insoluble

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Chemical Information

Molecular Weight 293.36
Formula
C16H23NO4
 
CAS No. 1104874-94-3
Storage powder
in solvent
Synonyms N/A
Smiles CCCCCC(=O)NC(CC1=CC=C(O)C=C1)C(=O)OC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04364230 Not yet recruiting Drug: 6MHP|Drug: NeoAg-mBRAF|Drug: PolyICLC|Drug: CDX-1140 Melanoma Craig L Slingluff Jr|Celldex Therapeutics|University of Virginia May 8 2020 Phase 1|Phase 2
NCT02382549 Recruiting Drug: dabrafenib|Biological: 6MHP|Drug: Trametinib Melanoma Craig L Slingluff Jr|National Cancer Institute (NCI)|University of Virginia April 2016 Early Phase 1
NCT02515227 Completed Biological: 6MHP|Drug: Pembrolizumab Melanoma Craig L Slingluff Jr|National Cancer Institute (NCI)|University of Virginia November 2015 Phase 1|Phase 2
NCT00742209 Completed Drug: GSK1838262|Drug: Placebo Migraine Disorders|Migraine XenoPort Inc.|GlaxoSmithKline August 2008 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID