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SBE-β-CD Hydrotropic Agents chemical

Cat.No.S4592

SBE-β-CD is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
SBE-β-CD Hydrotropic Agents chemical Chemical Structure

Chemical Structure

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight Formula

C42H70-nO35.nNa.n(C4H8O3S)

 Storage (From the date of receipt)
CAS No. 182410-00-0 Download SDF Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms Sulfobutylether-β-Cyclodextrin SMILES [Na+].[Na+].OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(OCCCC[S]([O-])(=O)=O)C(OC5COCCCC[S]([O-])(=O)=O)OC6=C(CO)OC(OC7C(O)C(O)C(OC7CO)OC8C(O)C(O)C(OC8CO)OC1C(O)C2O)C(O)C6O

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Mechanism of Action

References

Applications

Methods Biomarkers Images PMID
Western blot DII1 / Jag1 / N1ICD / β-actin DII1 / N1ICD / Jag1 / β-actin AKT / Cyclin D3 / Grb2 PARP / c-myc / CIP2A / E2F1 / β-Actin
S4592-WB-1
30407728
PAS staining tubular injury
S4592-PAS-staining-1
30407728
Immunofluorescence MOG / GSTπ / pCXCR4
S4592-IF-1
24733828

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-10-10)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02909036 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Amyloidosis
Memorial Sloan Kettering Cancer Center
 2016-09 PHASE1
NCT04627831 WITHDRAWN
Contrast-induced Nephropathy
Ligand Pharmaceuticals
 2022-01 PHASE2
NCT03869983 COMPLETED
Contrast-induced Nephropathy; Coronary Angiography
CyDex Pharmaceuticals, Inc.
 2019-04-12
NCT02723201 COMPLETED
Healthy
Takeda
 2016-04-28 PHASE1
NCT02250222 COMPLETED
Type 2 Diabetes Mellitus
Ligand Pharmaceuticals
 2014-10 PHASE1
NCT01919684 COMPLETED
Type 2 Diabetes Mellitus
Ligand Pharmaceuticals
 2013-11 PHASE1

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