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PEG400 Hydrotropic Agents chemical

Cat.No.S6705

PEG400b (Polyethylene glycol 400) is a commonly used co-solvent used in a variety of pharmaceutical formulations. It acts as a good solubilizer and surfactant and has the potential to improve the bioavailability of drugs. This compound significantly accelerates the metabolism of baicalein and increases the penetration of BG and B6G in Caco‐2 cells.
PEG400 Hydrotropic Agents chemical Chemical Structure
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Quality Control

Batch: Purity: 99%
99

Solubility

In vitro
Batch:

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight Formula

(C2H4O)nH2O

 Storage (From the date of receipt) 3 years room temperature liquid
CAS No. 25322-68-3 --

Read more about storage stability stock solution CAS number

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-02)

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Functional Constipation
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Colonoscopy Preparation
Medical University of Warsaw
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NCT06349031 UNKNOWN
Functional Constipation; Fecal Impaction; Constipation - Functional; Constipation Chronic Idiopathic; Pediatric Functional Constipation
Institute of Medical Sciences and SUM Hospital
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Dry Eye Disease
Calm Water Therapeutics LLC
 2022-12-12
NCT03146052 COMPLETED
Polyps; Colon Preparation
ASST Rhodense
 2017-03-27
NCT02289365 UNKNOWN
Radiodermatitis
Joben Bio-Medical Co., Ltd.
 2014-11 PHASE2

Read more about Clinical Trials

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