WS3

Catalog No.S7441

WS3 Chemical Structure

Molecular Weight(MW): 569.58

WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

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Biological Activity

Description WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Targets
EBP1 [1] IκB kinase [1]
In vitro

WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. [1] WS3 reversibly induces proliferation of primary fetal and adult human retinal pigment epithelial (RPE) cells. [2]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: R7T1 cells
  • Concentrations: ~10 μM
  • Incubation Time: 4 days
  • Method: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (175.56 mM)
Ethanol 80 mg/mL warmed (140.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 569.58
Formula

C28H30F3N7O3

CAS No. 1421227-52-2
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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IκB/IKK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID