IKK-16 (IKK Inhibitor VII)
Molecular Weight(MW): 483.63
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.
Cited by 16 Publications
3 Customer Reviews
mBM-DCs were preincubated with the indicated inhibitors for 30 min and then treated with or without 20 mM dryocrassin. After 1 h of incubation, the cells were washed, followed by stimulation with 100 ng/ml LPS for 20 h. The detection of phosphorylated forms of IKK, JNK, and p38 MAPK by Western blot analysis with specific antibodies.
Cell Transplant, 2014, 23(4-5): 641-56. IKK-16 (IKK Inhibitor VII) purchased from Selleck.
(B) Cells were treated with an IKK 16 (10 μmol/ml) for 1 hr. The cells were then cultured with TGF-β1 (20 ng/ml) and AT-RvD1 (20 ng/ml). After incubation, the gene expressions of Nrf2 and Smad7 were determined by RT-PCR. The effects of the Nrf2 and Smad7 gene expressions by AT-RvD1 in the TGF-β1-induced EndMT process had been altered.
Biomol Ther (Seoul), 2016, 24(2):132-9.. IKK-16 (IKK Inhibitor VII) purchased from Selleck.
Purity & Quality Control
Choose Selective IκB/IKK Inhibitors
|Description||IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.|
IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker. 
|In vivo||IKK-16 is orally bio-available in rats and mice, and it inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.|
|In vitro||DMSO||97 mg/mL (200.56 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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