Name: Trastuzumab-deruxtecan (DS-8201a, T-DXd)
Brand: Selleck Chemicals
SKU: E0200
Rating: 5 (1 reviews)

Trastuzumab deruxtecan (DS-8201a, T-DXd) is an antibody-drug conjugate (ADC) composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody and a cytotoxic topoisomerase I inhibitor. Trastuzumab deruxtecan shows durable antitumor activity. Trastuzumab deruxtecan has a molecular weight of 153KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4001.

Trastuzumab-deruxtecan (DS-8201a, T-DXd) Chemical Structure

CAS: 1826843-81-5 (ADC)

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Purity & Quality Control

Batch: E020001 Purity: 99.86%

99.86

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Biological Activity

Description

Trastuzumab deruxtecan (DS-8201a, T-DXd) is an antibody-drug conjugate (ADC) composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody and a cytotoxic topoisomerase I inhibitor. Trastuzumab deruxtecan shows durable antitumor activity. Trastuzumab deruxtecan has a molecular weight of 153KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4001.

References

[1] Salvatore Siena, et al. Lancet Oncol . 2021 Jun;22(6):779-789.

Chemical Information & Solubility

Molecular Weight	153000	Formulation	10mg/mL in PBS
DAR	7.8	Antibody	Trastuzumab
ADC Cytotoxin	DXd	Formula	N/A
CAS No.	1826843-81-5 (ADC)	Storage (From the date of receipt)	1 year -80°C in solvent
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
What’s the solvent of this ADC drug? And what’s its concentration?

Answer:
The solvent is a PBS solution. The concentration is 10mg/ml.

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