Home Others Antibody-Drug Conjugate chemical Trastuzumab-deruxtecan (DS-8201a, T-DXd)

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Trastuzumab-deruxtecan (DS-8201a, T-DXd) Antibody-Drug Conjugate chemical

Cat.No.E0200

Trastuzumab deruxtecan (DS-8201a, T-DXd) is an antibody-drug conjugate (ADC) composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody and a cytotoxic topoisomerase I inhibitor. Trastuzumab deruxtecan shows durable antitumor activity. Trastuzumab deruxtecan has a molecular weight of 153KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4001.
Trastuzumab-deruxtecan (DS-8201a, T-DXd) Antibody-Drug Conjugate chemical Chemical Structure

Chemical Structure

Molecular Weight: 153000

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Quality Control

Batch: E020001 Purity: 99.86%
99.86

Solubility

In vitro
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 153000 Formulation 10mg/mL in PBS DAR 7.8
Antibody Trastuzumab ADC Cytotoxin DXd Formula N/A
CAS No. 1826843-81-5 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-19)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07553390 NOT_YET_RECRUITING
Breast Cancer
M.D. Anderson Cancer Center
 2026-10-01 PHASE1
NCT07060807 RECRUITING
Breast Neoplasms
Merck Sharp & Dohme LLC
 2025-07-21 PHASE3
NCT07578116 NOT_YET_RECRUITING
Anatomic Stage IV Breast Cancer AJCC v8; Metastatic HER2-Positive Breast Carcinoma; Oligometastatic Breast Carcinoma
SWOG Cancer Research Network
 2027-03-09 PHASE3
NCT06643585 RECRUITING
Breast Cancer
Prof. Wolfgang Janni
 2025-04-22 PHASE3
NCT07022483 RECRUITING
Endometrial Cancer
Daiichi Sankyo
 2025-09-30 PHASE3
NCT07630103 NOT_YET_RECRUITING
Advanced Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2026-06 PHASE2

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Frequently Asked Questions

Question 1:
What's the solvent of this ADC drug? And what's its concentration?

Answer:
Its solvent is a PBS solution, and the concentration is 10mg/ml.