Trastuzumab-Emtansine（T-DM1） CAS Number 1018448-65-1 (ADC)

CAS No. 1018448-65-1 (ADC)

Chemical Structure

Check the Trastuzumab-Emtansine（T-DM1） product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number	1018448-65-1 (ADC)
Molecular Formula
Molecular Weight (MW)	145000

Biological Activity

Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) comprising the HER2-targeted monoclonal antibody trastuzumab linked to the cytotoxic agent DM1. Upon binding to HER2 on tumor cells, T-DM1 undergoes receptor-mediated internalization and lysosomal degradation, releasing DM1 catabolites that disrupt microtubule polymerization. Additionally, T-DM1 retains trastuzumab-mediated inhibition of HER2 signaling pathways, such as AKT/mTOR, and induces antibody-dependent cell-mediated cytotoxicity, ultimately leading to mitotic arrest and apoptosis.^[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass

Solubility

Reference

[1] Lewis Phillips GD, et al. Cancer Res. 2008;68(22):9280-90.

[2] Junttila TT, et al. Breast Cancer Res Treat. 2011;128(2):347-56.