Sakuranetin

Catalog No.S0938 Batch:S093801

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Technical Data

Formula

C16H14O5
Molecular Weight 286.28 CAS No. 2957-21-3
Solubility (25°C)* In vitro DMSO 57 mg/mL (199.1 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
In vitro

Sakuranetin can significantly inhibit NO induction and inducible nitric oxide synthase (iNOS) expression, also decrease the expression of type 1 IL-1 receptor gene and phosphorylation of Akt.[2]
In vivo

sakuranetin prevents and reduces pulmonary inflammation induced by LPS through modulating oxidative stress, the NF-κB pathway, and lung function.[3]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    IL-1β-treated rat hepatocytes

  • Concentrations

    20, 40, 60 μM

  • Incubation Time

    8 h

  • Method

    Hepatocytes are treated with 1 nM IL-1β in the absence or presence of sakuranetin for 8 h. The NO levels are then measured in the medium.
Animal Study:

[3]
  • Animal Models

    mice of lipopolysaccharide (LPS)-induced acute lung injury (ALI)

  • Dosages

    20 mg·kg−1·animal−1

  • Administration

    i.t.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.