Name: Ribitol
Brand: Selleck Chemicals
SKU: S2612
Rating: 5 (1 reviews)

Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.

Ribitol Chemical Structure

CAS: 488-81-3

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Biological Activity

Description	Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.

In vitro
In vitro	Ribitol is a crystalline pentose alcohol. ^[1] Ribitol is characterized from the plant Adonis vernalis. ^[2] Ribitol in 10% NFSM suspending medium exerts 1.45 to 2.18 times the protective effect exerted by glycerol at equal concentration. The cryoprotective action of Ribitol reaches its highest level at 0.75 M. For 11 of the 13 organisms tested including S. lactis T164, the degree of protection conferred by Ribitol is >80%. Ribitol has a strong protective effect on lactic acid bacteria during freeze-drying. ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03128489	Withdrawn	Diphtheria\|Acellular Pertussis\|Haemophilus Influenzae Type b\|Tetanus\|Poliomyelitis	GlaxoSmithKline	December 1 2017	Phase 3
NCT02853929	Completed	Diphtheria\|Hepatitis B\|Acellular Pertussis\|Haemophilus Influenzae Type b\|Tetanus\|Poliomyelitis\|Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b Vaccines	GlaxoSmithKline	September 19 2016	Phase 4

References

Chemical Information & Solubility

Molecular Weight	152.15	Formula	C₅H₁₂O₅
CAS No.	488-81-3	SDF	Download Ribitol SDF
Smiles	C(C(C(C(CO)O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 31 mg/mL ( (203.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 31 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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