CAS No. 503468-95-9
Batch:
Purity:99.73
Chemical Structure
Check the
NU7441 (KU-57788)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one | |
|---|---|---|
| CAS Number | 503468-95-9 | |
| Molecular Formula |
C25H19NO3S |
|
| Molecular Weight (MW) | 413.49 | |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56 | |
| InChIKey | JAMULYFATHSZJM-UHFFFAOYSA-N |
NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = that also inhibits mTOR (IC50 = and PI3K (IC50 =. By suppressing DNA-PK-mediated non-homologous end joining repair of double-strand breaks, it disrupts DNA damage repair pathways, promoting G2/M cell cycle arrest and potentiating cytotoxicity induced by ionizing radiation and topoisomerase II inhibitors. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(12.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(7.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(36.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(7.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(7.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- NU7441 (KU-57788) Mechanism of Action: DNA-PK Inhibition in Mammalian Cell Research
- NU7441 (KU-57788) Working Concentration | Cell Culture | Treatment
- NU7441 (KU-57788) Solubility in DMSO
- NU7441 (KU-57788) Stock Solution
- NU7441 (KU-57788) Storage
- NU7441 (KU-57788) Stability
- NU7441 (KU-57788) Combination Database
- NU7441 (KU-57788) Molecular Weight
- NU7441 (KU-57788) SMILES
- NU7441 (KU-57788) Chemical Structure (2D and 3D)
- NU7441 (KU-57788) IC50 for Cell-based and Cell-free Assays
- NU7441 (KU-57788) Tocris (3712)? Try a better option.
- NU7441 (KU-57788) Sigma (SML3923)? Try a better option.
- NU7441 (KU-57788) Cayman (14881)? Try a better option.
- NU7441 (KU-57788) APExBIO (A8315)? Try a better option.
- NU7441 (KU-57788) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.