NU7441 (KU-57788) is a potent, selective ATP-competitive DNA-PK inhibitor. It affects NHEJ, cGAS-STING, and Smad2/3 signaling pathways by inhibiting DNA-PKcs kinase activity, effectively suppressing cancer cell proliferation and fibrosis while promoting homology-directed repair.
NU7441 (KU-57788) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for NU7441 (KU-57788) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.