CAS No. 159989-64-7
Batch:
Purity:96.88
Chemical Structure
Check the
Nelfinavir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide | |
|---|---|---|
| CAS Number | 159989-64-7 | |
| Molecular Formula |
C32H45N3O4S |
|
| Molecular Weight (MW) | 567.78 | |
| InChIKey | QAGYKUNXZHXKMR-HKWSIXNMSA-N |
Biological Activity
Nelfinavir (AG-1341) is an HIV protease inhibitor that prevents viral polyprotein cleavage and viral maturation. Beyond its antiretroviral function, Nelfinavir induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in various cellular models by downregulating AKT pathway signaling. Furthermore, it demonstrates targeted biological activity by suppressing Streptolysin S production in Streptococcus pyogenes, effectively impairing key bacterial virulence mechanisms. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.