UCB-9260

Catalog No.S3231

For research use only.

UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13  nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.

UCB-9260 Chemical Structure

CAS No. 1515888-53-5

Purity & Quality Control

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Biological Activity

Description UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13  nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
Targets
TNF [1]
(Cell-free assay)
NF-κB [1]
(Cell-free assay)
13 nM(Kd) 202 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 85 mg/mL
(200.7 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 423.51
Formula

C26H25N5O

CAS No. 1515888-53-5
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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