Home Apoptosis TNF-alpha inhibitor - NF-κB inhibitor UCB-9260

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UCB-9260 TNF-alpha inhibitor

Cat.No.S3231

UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. This compound binds TNF with Kd of 13  nM. It also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
UCB-9260 TNF-alpha inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 423.51

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S323101 DMSO]85 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.68%
99.68

Chemical Information, Storage & Stability

Molecular Weight 423.51 Formula

C26H25N5O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1515888-53-5 -- Storage of Stock Solutions

Synonyms N/A Smiles C[N]1C=C(C=N1)C2=CC3=C(C=C2)N=C(C(O)C4=CC=NC=C4)[N]3CC5=C(C)C=CC(=C5)C

Solubility

In vitro
Batch:

DMSO : 85 mg/mL ( (200.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
TNF [1]
(Cell-free assay)
13 nM(Kd)
NF-κB [1]
(Cell-free assay)
202 nM
References

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