Home Apoptosis TNF-alpha inhibitor - NF-κB inhibitor UCB-9260 For research use only.

UCB-9260

UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13  nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.

UCB-9260 Chemical Structure

UCB-9260 Chemical Structure

CAS: 1515888-53-5

Purity & Quality Control

Batch: S323101 DMSO] 85 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.68%
99.68

UCB-9260 Related Products

Signaling Pathway

TNF-alpha Signaling Pathways

TNF-alpha Signaling Pathway

Choose Selective TNF-alpha Inhibitors

Biological Activity

Description UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13  nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
Targets
TNF [1]
(Cell-free assay)		 NF-κB [1]
(Cell-free assay)
13 nM(Kd) 202 nM

Chemical Information & Solubility

Molecular Weight 423.51 Formula

C26H25N5O
CAS No. 1515888-53-5 SDF --
Smiles C[N]1C=C(C=N1)C2=CC3=C(C=C2)N=C(C(O)C4=CC=NC=C4)[N]3CC5=C(C)C=CC(=C5)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 85 mg/mL ( (200.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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