CAS No. 154947-66-7(free base)
Batch:
Purity:98.62
Chemical Structure
Check the
LL-37 acetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 154947-66-7(free base) | |
|---|---|---|
| Molecular Formula |
C207H344N60O55 |
|
| Molecular Weight (MW) | 4553.31 |
LL-37 acetate is an amphipathic, cathelicidin-derived antimicrobial peptide that acts as an innate host defense effector and chemotactic factor. It permeabilizes bacterial inner and outer membranes and neutralizes lipopolysaccharide to exert broad-spectrum antimicrobial activity against Gram-positive and Gram-negative pathogens. Additionally, LL-37 functions via formyl peptide receptor-like 1 (FPRL1) to recruit neutrophils, monocytes, and T cells, thereby regulating host immune responses and tissue repair.[1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 90 mg/mL |
| Ethanol | 90 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.