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L-Tyrosine

Synonyms: (S)-Tyrosine, P-Tyrosine, L-p-Tyrosine

L-tyrosine ((S)-Tyrosine, P-Tyrosine, L-p-Tyrosine) is a non-essential amino acid. In animals it is synthesized from Ephenylalanine.

L-Tyrosine Chemical Structure

L-Tyrosine Chemical Structure

CAS: 60-18-4

Purity & Quality Control

Batch: S460801 5%TFA] 6.02 mg/mL] false] DMSO] 0.1 mg/mL] false] Water] Insoluble] false Purity: 99.94%
99.94

L-Tyrosine Related Products

Biological Activity

Description L-tyrosine ((S)-Tyrosine, P-Tyrosine, L-p-Tyrosine) is a non-essential amino acid. In animals it is synthesized from Ephenylalanine.
In vitro
In vitro L-tyrosine in vitro inhibits citrate synthase activity in the posterior cortex. Succinate dehydrogenase activity is increased in the posterior cortex, hippocampus, striatum and liver. Complex I activity is inhibited in the hippocampus, complex II activity is also inhibited in the hippocampus and in the posterior cortex and liver, complex II–III activity is not altered by L-tyrosine and complex IV activity decreased in the posterior cortex[1].
In Vivo
In vivo Acute administration of L-tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum[1].
Animal Research Animal Models Wistar rats
Dosages 500 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 181.19 Formula

C9H11NO3
CAS No. 60-18-4 SDF Download L-Tyrosine SDF
Smiles C1=CC(=CC=C1CC(C(=O)O)N)O
Storage (From the date of receipt)

In vitro
Batch:

5%TFA : 6.02 mg/mL

DMSO : 0.1 mg/mL ( (0.55 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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