JNJ-42165279

For research use only.

Catalog No.S0497 Synonyms: JNJ-5279

JNJ-42165279 Chemical Structure

CAS No. 1346528-50-4

JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.

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Biological Activity

Description JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.
Targets
recombinant human FAAH [1]
(Cell-free assay)
recombinant rat FAAH [1]
(Cell-free assay)
70 nM 313 nM

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 410.80
Formula

C18H17ClF2N4O3

CAS No. 1346528-50-4
Storage powder
in solvent
Synonyms JNJ-5279
Smiles C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03564379 Completed Drug: JNJ-42165279|Drug: Placebo Healthy Janssen Research & Development LLC June 12 2018 Phase 1
NCT02498392 Completed Drug: JNJ-42165279|Other: Placebo Depressive Disorder|Anxiety Janssen Research & Development LLC October 7 2015 Phase 2
NCT02169973 Completed Drug: JNJ-42165279|Drug: 11C-MK-3168 Healthy Janssen Research & Development LLC February 2014 Phase 1
NCT02065739 Completed Drug: JNJ-42165279|Drug: Itraconazole Healthy Janssen Pharmaceutica N.V. Belgium January 2014 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAAH Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID