Home Metabolism FAAH inhibitor JNJ-42165279

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JNJ-42165279 FAAH inhibitor

Cat.No.S0497

JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.
JNJ-42165279 FAAH inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 410.80

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S049701 DMSO]82 mg/mL]false]Ethanol]82 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 410.80 Formula

C18H17ClF2N4O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1346528-50-4 -- Storage of Stock Solutions

Synonyms JNJ-5279 Smiles C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl

Solubility

In vitro
Batch:

DMSO : 82 mg/mL ( (199.61 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
recombinant human FAAH [1]
(Cell-free assay)
70 nM
recombinant rat FAAH [1]
(Cell-free assay)
313 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03564379 Completed
Healthy
Janssen Research & Development LLC
 June 12 2018 Phase 1
NCT02498392 Completed
Depressive Disorder|Anxiety
Janssen Research & Development LLC
 October 7 2015 Phase 2
NCT02169973 Completed
Healthy
Janssen Research & Development LLC
 February 2014 Phase 1
NCT02065739 Completed
Healthy
Janssen Pharmaceutica N.V. Belgium
 January 2014 Phase 1

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