JNJ-42165279

Catalog No.S0497 Synonyms: JNJ-5279

For research use only.

JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.

JNJ-42165279 Chemical Structure

CAS No. 1346528-50-4

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Biological Activity

Description JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.
Targets
recombinant human FAAH [1]
(Cell-free assay)
recombinant rat FAAH [1]
(Cell-free assay)
70 nM 313 nM

Protocol (from reference)

Chemical Information

Molecular Weight 410.80
Formula

C18H17ClF2N4O3

CAS No. 1346528-50-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03564379 Completed Drug: JNJ-42165279|Drug: Placebo Healthy Janssen Research & Development LLC June 12 2018 Phase 1
NCT02498392 Completed Drug: JNJ-42165279|Other: Placebo Depressive Disorder|Anxiety Janssen Research & Development LLC October 7 2015 Phase 2
NCT02169973 Completed Drug: JNJ-42165279|Drug: 11C-MK-3168 Healthy Janssen Research & Development LLC February 2014 Phase 1
NCT02065739 Completed Drug: JNJ-42165279|Drug: Itraconazole Healthy Janssen Pharmaceutica N.V. Belgium January 2014 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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