CAS No. 120926-46-7

Batch: Purity:99.89
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Isoliquiritin apioside Chemical Structure
Chemical Structure
Check the Isoliquiritin apioside product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
CAS Number 120926-46-7
Molecular Formula

C26H30O13
Molecular Weight (MW) 550.51
SMILES C1C(C(C(O1)OC2C(C(C(OC2OC3=CC=C(C=C3)C=CC(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O
InChIKey VMMVZVPAYFZNBM-KVFWHIKKSA-N

Biological Activity

Isoliquiritin apioside is a natural flavonoid component isolated from Glycyrrhizae radix rhizome that functions as an inhibitor of matrix metalloproteinase activities. It suppresses PMA-induced activation of the MAPK and NF-kB signaling pathways. Downstream inhibition of these pathways attenuates extracellular matrix degradation, leading to anti-metastatic and anti-angiogenic effects in malignant cancer cells and endothelial cells without cytotoxicity. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (181.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 70 mg/mL
Water 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kessenbrock K, et al. Cell. 2010;141(1):52-67.

[2] Karin M. Nature. 2006;441(7092):431-6.

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Note: Technical data last updated: Sep 1, 2026.