CAS No. 312538-03-7
Batch:
Purity:99.28
Chemical Structure
Check the
IQ 3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(E)-indeno[1,2-b]quinoxalin-11-ylideneamino] furan-2-carboxylate | |
|---|---|---|
| CAS Number | 312538-03-7 | |
| Molecular Formula |
C20H11N3O3 |
|
| Molecular Weight (MW) | 341.32 | |
| SMILES | C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5 | |
| InChIKey | WBSWWONMTZEOGS-PTGBLXJZSA-N |
IQ 3 is a specific c-Jun N-terminal kinase (JNK) inhibitor targeting JNK3, JNK1, and JNK2. It suppresses LPS-induced NF-κB/AP-1 transcriptional activity with an IC50 of. By attenuating JNK signaling, IQ 3 downregulates inflammatory responses and inhibits the downstream production of pro-inflammatory cytokines, including TNF-α and IL-6, in vitro. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(14.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.