IMR-1

Catalog No.S8280 Batch:S828001

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Technical Data

Formula

C15H15NO5S2
Molecular Weight 353.41 CAS No. 310456-65-6
Solubility (25°C)* In vitro DMSO 70 mg/mL (198.07 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.
Targets
Notch [1]
(Cell-free assay)
26 μM

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    OE33 and 786-0 cells

  • Concentrations

    5, 10, 15, 25 μM

  • Incubation Time

    --

  • Method

    ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control.
Animal Study:

[1]
  • Animal Models

    xenograft model(mouse)

  • Dosages

    15 mg/kg

  • Administration

    i.p.

Selleck's IMR-1 has been cited by 6 publications

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway [ Cell Death Dis, 2022, 13(11):945] PubMed: 36351890
Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway [ Cell Biosci, 2021, 11(1):87] PubMed: 34001269
Dual targeting of Notch and Wnt/β-catenin pathways: Potential approach in triple-negative breast cancer treatment [ Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-01988-x] PubMed: 33052427
Notch1 Signaling Pathway Promotes Proliferation and Mediates Differentiation Direction in Hippocampus of Streptococcus pneumonia Meningitis Rats. [ J Infect Dis, 2019, 220(12):1977-1988] PubMed: 31433841
Glioblastoma Stem Cell-Derived Exosomes Enhance Stemness and Tumorigenicity of Glioma Cells by Transferring Notch1 Protein. [ Cell Mol Neurobiol, 2019, 10.1007/s10571-019-00771-8] PubMed: 31853695
Cbfα1 hinders autophagy by DSPP upregulation in odontoblast differentiation. [ Int J Biochem Cell Biol, 2019, 115:105578] PubMed: 31374250

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.