IEM 1754 2HBr

Catalog No.S2860

For research use only.

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

IEM 1754 2HBr Chemical Structure

CAS No. 162831-31-4

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Biological Activity

Description IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Targets
GluR1 [1] GluR3 [1]
6 μM 6 μM
In vitro

IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 82 mg/mL
(198.9 mM)
Water 82 mg/mL
(198.9 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 412.25
Formula

C16H30N2.2HBr

CAS No. 162831-31-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2CC3CC1CC(C2)(C3)CNCCCCCN.Br.Br

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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