Home Transmembrane Transporters CFTR chemical Icenticaftor (QBW251)

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Icenticaftor (QBW251) CFTR chemical

Cat.No.S9972

Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells.

Icenticaftor (QBW251) CFTR chemical Chemical Structure

Chemical Structure

Molecular Weight: 361.24

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Quality Control

Batch: S997201 DMSO]72 mg/mL]false]Ethanol]72 mg/mL]false]Water]Insoluble]false Purity: 99.89%
99.89

Solubility

In vitro
Batch:

DMSO : 72 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble

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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 361.24 Formula

C12H13F6N3O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1334546-77-8 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
F508del CFTR
79 nM(EC50)
G551D CFTR
497 nM(EC50)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-09-26)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04396366 TERMINATED
Bronchiectasis
Novartis Pharmaceuticals
 2021-02-02 PHASE2
NCT04587622 COMPLETED
Hepatic Failure
Novartis Pharmaceuticals
 2020-10-30 PHASE1
NCT04268823 TERMINATED
Chronic Obstructive Pulmonary Disease
Novartis Pharmaceuticals
 2020-09-10 PHASE2
NCT04072887 COMPLETED
Pulmonary Disease, Chronic Obstructive
Novartis Pharmaceuticals
 2019-09-12 PHASE2
NCT04396366 Terminated
Bronchiectasis
Novartis Pharmaceuticals|Innovative Medicines Initiative|Novartis
 2021-02-02 Phase 2
NCT04587622 Completed
Hepatic Failure
Novartis Pharmaceuticals|Novartis
 2020-10-30 Phase 1

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