Halobetasol Propionate

Catalog No.S4089 Synonyms: BMY-30056, CGP-14458

Halobetasol Propionate Chemical Structure

Molecular Weight(MW): 484.96

Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.

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USD 97 In stock
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Biological Activity

Description Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.
Targets
PLA2 [1]
In vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1]

Protocol

Solubility (25°C)

In vitro DMSO 97 mg/mL (200.01 mM)
Ethanol 38 mg/mL (78.35 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 484.96
Formula

C25H31ClF2O5

CAS No. 66852-54-8
Storage powder
in solvent
Synonyms BMY-30056, CGP-14458

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03298581 Withdrawn Plaque Psoriasis Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services November 1 2017 Phase 2
NCT03298581 Withdrawn Plaque Psoriasis Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services November 1 2017 Phase 2
NCT03245385 Terminated Atopic Dermatitis Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services July 24 2017 Phase 2
NCT03245385 Terminated Atopic Dermatitis Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services July 24 2017 Phase 2
NCT01610596 Completed Psoriasis|Plaque Psoriasis Therapeutics Inc. November 2011 Phase 2
NCT01610596 Completed Psoriasis|Plaque Psoriasis Therapeutics Inc. November 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Phospholipase (e.g. PLA) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID