Home Metabolism Phospholipase (e.g. PLA) inhibitor Halobetasol Propionate

Halobetasol Propionate

Catalog No.S4089 Synonyms: BMY-30056, CGP-14458,Ulobetasol propionate

For research use only.

Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.

Halobetasol Propionate Chemical Structure

CAS No. 66852-54-8

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Phospholipase (e.g. PLA) Signaling Pathways

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Biological Activity

Description Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.
Targets
PLA2 [1]
In vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 484.96
Formula

C25H31ClF2O5
CAS No. 66852-54-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03988439 Recruiting Drug: IDP-118 Lotion Psoriasis Bausch Health Americas Inc. March 24 2021 Phase 4
NCT03987763 Recruiting Drug: IDP-122 Lotion Psoriasis Bausch Health Americas Inc. October 22 2019 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-11-29)

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