Halobetasol Propionate

Synonyms: BMY-30056, CGP-14458,Ulobetasol propionate

Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.

Halobetasol Propionate Chemical Structure

Halobetasol Propionate Chemical Structure

CAS: 66852-54-8

Purity & Quality Control

Batch: S408901 DMSO] 97 mg/mL] false] Ethanol] 38 mg/mL] false] Water] Insoluble] false Purity: 99.92%
99.92

Halobetasol Propionate Related Products

Choose Selective Phospholipase (e.g. PLA) Inhibitors

Biological Activity

Description Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.
Targets
PLA2 [1]
In vitro
In vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03988439 Recruiting
Psoriasis
Bausch Health Americas Inc.
March 24 2021 Phase 4
NCT03987763 Recruiting
Psoriasis
Bausch Health Americas Inc.
October 22 2019 Phase 4

Chemical Information & Solubility

Molecular Weight 484.96 Formula

C25H31ClF2O5

CAS No. 66852-54-8 SDF Download Halobetasol Propionate SDF
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 97 mg/mL ( (200.01 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 38 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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