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Halobetasol Propionate

Name: Halobetasol Propionate
Brand: Selleck Chemicals
SKU: S4089
Rating: 5 (0 reviews)

Catalog No.S4089 Synonyms: BMY-30056, CGP-14458

For research use only.

Halobetasol Propionate (BMY-30056, CGP-14458) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.

Halobetasol Propionate Chemical Structure

CAS No. 66852-54-8

Purity & Quality Control

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Phospholipase (e.g. PLA) Signaling Pathways

Phospholipase (e.g. PLA) Signaling Pathway Map

Biological Activity

Description

Targets

PLA2 ^[1]

In vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.^[1]

Protocol (from reference)

References

[1] Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	484.96
Formula	C₂₅H₃₁ClF₂O₅
CAS No.	66852-54-8
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl

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In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03988439	Recruiting	Drug: IDP-118 Lotion	Psoriasis	Bausch Health Americas Inc.	March 24 2021	Phase 4
NCT03987763	Recruiting	Drug: IDP-122 Lotion	Psoriasis	Bausch Health Americas Inc.	October 22 2019	Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

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Handling Instructions

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