Halobetasol Propionate
Catalog No.S4089 Synonyms: BMY-30056, CGP-14458
Molecular Weight(MW): 484.96
Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.
Purity & Quality Control
Choose Selective Phospholipase (e.g. PLA) Inhibitors
Biological Activity
| Description | Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. | |
|---|---|---|
| Targets |
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| In vitro |
Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 97 mg/mL (200.01 mM) |
|---|---|---|
| Ethanol | 38 mg/mL (78.35 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 484.96 |
|---|---|
| Formula | C25H31ClF2O5 |
| CAS No. | 66852-54-8 |
| Storage | powder |
| in solvent | |
| Synonyms | BMY-30056, CGP-14458 |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03298581 | Withdrawn | Plaque Psoriasis | Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services | November 1 2017 | Phase 2 |
| NCT03298581 | Withdrawn | Plaque Psoriasis | Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services | November 1 2017 | Phase 2 |
| NCT03245385 | Terminated | Atopic Dermatitis | Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services | July 24 2017 | Phase 2 |
| NCT03245385 | Terminated | Atopic Dermatitis | Sun Pharmaceutical Industries Limited|Novum Pharmaceutical Research Services | July 24 2017 | Phase 2 |
| NCT01610596 | Completed | Psoriasis|Plaque Psoriasis | Therapeutics Inc. | November 2011 | Phase 2 |
| NCT01610596 | Completed | Psoriasis|Plaque Psoriasis | Therapeutics Inc. | November 2011 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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