CAS No. 941987-60-6
Batch:
Purity:99.94
Chemical Structure
Check the
H-151
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea | |
|---|---|---|
| CAS Number | 941987-60-6 | |
| Molecular Formula |
C17H17N3O |
|
| Molecular Weight (MW) | 279.34 | |
| SMILES | CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32 | |
| InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
H-151 is a potent, selective, and covalent inhibitor of stimulator of interferon genes (STING). It targets conserved cysteine residue Cys91 on STING to covalently block its palmitoylation and subsequent activation. Inhibition of STING prevents downstream phosphorylation of TBK1 and IRF3, effectively suppressing type I interferon production and attenuating systemic autoinflammatory signaling in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
56 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
56 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
| DMSO |
210 mg/mL
(751.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- H-151 Mechanism of Action: STING Inhibition in Macrophage Research
- H-151: Selectivity & Specificity
- H-151 Working Concentration | Cell Culture | Treatment
- H-151 Solubility in DMSO
- H-151 Stock Solution
- H-151 Storage
- H-151 Stability
- H-151 Molecular Weight
- H-151 SMILES
- H-151 Chemical Structure (2D and 3D)
- H-151 Sigma (SML2437)? Try a better option.
- H-151 MedChemExpress (HY-112693)? Try a better option.
- H-151 Tocris (6675)? Try a better option.
- H-151 Cayman (25857)? Try a better option.
- H-151 Abmole (M10126)? Try a better option.
- H-151 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.