CAS No. 871543-07-6

Batch: Purity:99.99
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H-1152 dihydrochloride Chemical Structure
Chemical Structure
Check the H-1152 dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 871543-07-6
Molecular Formula

C16H23Cl2N3O2S
Molecular Weight (MW) 392.34
SMILES Cl.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=C2C(=CN=C3)C

Biological Activity

H-1152 dihydrochloride is a membrane-permeable, selective Rho-associated protein kinase inhibitor targeting ROCK2, CaMK2, PKG, Aurora A, PKA, and PKC. Inhibition of the ROCK pathway suppresses actin cytoskeleton assembly and cell contractility, leading to downstream alterations in cell motility, vascular relaxation, and neurite outgrowth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 78 mg/mL
Ethanol 78 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sasaki Y, et al. Pharmacol Ther. 2002;93(2-3):225-32.

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Note: Technical data last updated: Sep 1, 2026.