Home Apoptosis Ferroptosis inhibitor - GPX inhibitor GPX4-IN-5

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GPX4-IN-5 Ferroptosis inhibitor

Cat.No.E6610

GPX4-IN-5 covalently inhibits GPX4 with an IC50 of 0.12 μM. This compound induces ferroptosis and exhibits anti-tumor activity. It has potential applications in triple-negative breast cancer (TNBC) research.
GPX4-IN-5 Ferroptosis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 381.78

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 381.78 Formula C18H17ClFNO5 Storage (From the date of receipt)
CAS No. 2922824-09-5 Download SDF Storage of Stock Solutions

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Mechanism of Action

In vivo
GPX4-IN-5 (Compound 18) (5-20 mg/kg, i.p., once a day for 21 consecutive days) has significant anti-tumor activity in the MDA-MB-231 xenograft tumor BALB/C nude mouse model, and has no obvious damage to kidney, liver and heart function. GPX4-IN-5 (20 mg/kg, i.p., once a day for 14 consecutive days) has no obvious blood toxicity, does not cause bone marrow suppression, and has no obvious damage to kidney, liver and heart function in the BALB/C nude mouse model.
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