GPX4-IN-5

Catalog No.E6610

Technical Data

Formula	C18H17ClFNO5
Molecular Weight	381.78	CAS No.	2922824-09-5
Solubility (25°C)*	In vitro


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description	GPX4-IN-5 is a covalent GPX4 inhibitor with an IC50 value of 0.12 μM. This compound induces ferroptosis and exhibits antitumor activity, particularly in triple-negative breast cancer (TNBC) research.
In vivo	GPX4-IN-5 (Compound 18) (5-20 mg/kg, i.p., once a day for 21 consecutive days) has significant anti-tumor activity in the MDA-MB-231 xenograft tumor BALB/C nude mouse model, and has no obvious damage to kidney, liver and heart function. This compound (20 mg/kg, i.p., once a day for 14 consecutive days) has no obvious blood toxicity, does not cause bone marrow suppression, and has no obvious damage to kidney, liver and heart function in the BALB/C nude mouse model.

Description

GPX4-IN-5 is a covalent GPX4 inhibitor with an IC50 value of 0.12 μM. This compound induces ferroptosis and exhibits antitumor activity, particularly in triple-negative breast cancer (TNBC) research.

In vivo

GPX4-IN-5 (Compound 18) (5-20 mg/kg, i.p., once a day for 21 consecutive days) has significant anti-tumor activity in the MDA-MB-231 xenograft tumor BALB/C nude mouse model, and has no obvious damage to kidney, liver and heart function. This compound (20 mg/kg, i.p., once a day for 14 consecutive days) has no obvious blood toxicity, does not cause bone marrow suppression, and has no obvious damage to kidney, liver and heart function in the BALB/C nude mouse model.

Protocol (from reference)

References

https://pubmed.ncbi.nlm.nih.gov/37452764/

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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