Home Microbiology Fungal inhibitor Ethylparaben For research use only.

Ethylparaben

Synonyms: Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate

Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.

Ethylparaben Chemical Structure

Ethylparaben Chemical Structure

CAS: 120-47-8

Purity & Quality Control

Batch: S452501 DMSO] 33 mg/mL] false] Ethanol] 33 mg/mL] false] Water] Insoluble] false Purity: 99.86%
99.86

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Biological Activity

Description Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
In vitro
In vitro Ethylparaben has weak estrogenic and weak anti-androgenic effects in vitro[2].
In Vivo
In vivo In vivo studies indicate that ethylparaben has estrogenic effects in vivo in immature and ovariotectomized mice. A study on fetal exposure to ethylparaben revealed no changes in male anogenital distance and no changes of fetal testosterone production, but changes in gene expression levels pointed to subtle endocrine disrupting effects. A limited study in young male rats found no adverse effects, although tendencies to lower sperm counts are seen. Ethylparaben causes vitellogenin induction in fish[2].
Animal Research Animal Models Wistar rats
Dosages 100, 200, and 400 mg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 166.17 Formula

C9H10O3
CAS No. 120-47-8 SDF Download Ethylparaben SDF
Smiles CCOC(=O)C1=CC=C(C=C1)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (198.59 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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