Ethylparaben

Catalog No.S4525 Batch:S452501

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Technical Data

Formula

C9H10O3

Molecular Weight 166.17 CAS No. 120-47-8
Solubility (25°C)* In vitro DMSO 33 mg/mL (198.59 mM)
Ethanol 33 mg/mL (198.59 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
In vitro Ethylparaben has weak estrogenic and weak anti-androgenic effects in vitro[2].
In vivo In vivo studies indicate that ethylparaben has estrogenic effects in vivo in immature and ovariotectomized mice. A study on fetal exposure to ethylparaben revealed no changes in male anogenital distance and no changes of fetal testosterone production, but changes in gene expression levels pointed to subtle endocrine disrupting effects. A limited study in young male rats found no adverse effects, although tendencies to lower sperm counts are seen. Ethylparaben causes vitellogenin induction in fish[2].

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Wistar rats

  • Dosages

    100, 200, and 400 mg/kg

  • Administration

    s.c.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.