CAS No. 480449-70-5

Batch: Purity:99.78
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Edoxaban Chemical Structure
Chemical Structure
Check the Edoxaban product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N'-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
CAS Number 480449-70-5
Molecular Formula

C24H30ClN7O4S
Molecular Weight (MW) 548.06
SMILES CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(Cl)C=C4)C(=O)N(C)C
InChIKey HGVDHZBSSITLCT-JLJPHGGASA-N

Biological Activity

Edoxaban (DU-176b) is an orally active, selective factor Xa (FXa) inhibitor that potently inhibits free FXa (Ki 0.561 nM) and prothrombinase complex (Ki 2.98 nM). By blocking FXa within the coagulation cascade, edoxaban prevents thrombin generation and subsequent fibrin clot formation. In animal models, it exerts strong antithrombotic effects, suppressing thrombus formation without markedly increasing bleeding risks. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (18.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Furugohri T, et al. J Thromb Haemost. 2008;6(9):1542-9.

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Note: Technical data last updated: Sep 1, 2026.