Home Microbiology Parasite inhibitor Decoquinate

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Decoquinate Parasite inhibitor

Cat.No.S4145

Decoquinate is a coccidiostat.
Decoquinate Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 417.54

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S414501 4-Methylpyridine]5 mg/mL]true]DMSO]0.01 mg/mL]false]Water]Insoluble]false Purity: 98.53%
98.53

Chemical Information, Storage & Stability

Molecular Weight 417.54 Formula

C24H35NO5

 Storage (From the date of receipt)
CAS No. 18507-89-6 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCCCCCCCCCOC1=C(C=C2C(=C1)C(=O)C(=CN2)C(=O)OCC)OCC

Solubility

In vitro
Batch:

4-Methylpyridine : 5 mg/mL

DMSO : 0.01 mg/mL (0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Decoquinate is a feed additive intended for the control of coccidiosis, a debilitating protozoal infection in poultry. The active agent is 4-hydroxyquinoline, incorporated at 0.6 % by weight in this feed additive. Evidence generated at the time of its introduction suggests that a product delivering 20-40 mg of this compound per kg complete feed is effective as a coccidiostat for chickens. It plays a role in the asexual propagation of coccidium. This chemical will stop the growth of ascospore by disturbing the DNA synthesis. It acts on the early living period of coccidium, so it can prevent the harm of the fowl's intestinal wall. [1]
In vivo
Decoquinate Premix can be absorbed fastly. It can reach the virtual concentration within 1 hour, and reach the highest concentration after 3 days. The NOEL of 15 mg/kg bw/day may be used as the basis for setting an acceptable daily intake (ADI) for this compound. [1]
References

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