Decoquinate

Catalog No.S4145

For research use only.

Decoquinate is a coccidiostat.

Decoquinate Chemical Structure

CAS No. 18507-89-6

Purity & Quality Control

Choose Selective Parasite Inhibitors

Biological Activity

Description Decoquinate is a coccidiostat.
In vitro

Decoquinate is a feed additive intended for the control of coccidiosis, a debilitating protozoal infection in poultry. The active agent is 4-hydroxyquinoline, incorporated at 0.6 % by weight in the feed additive. Evidence generated at the time of its introduction suggests that a product delivering 20-40 mg of decoquinate per kg complete feed is effective as a coccidiostat for chickens. Decoquinate plays a role in the asexual propagation of coccidium. It will stop the growth of ascospore by disturbing the DNA synthesis. Decoquinate acts on the early living period of coccidium, so it can prevent the harm of the fowl's intestinal wall. [1]

In vivo Decoquinate Premix can be absorbed fastly. It can reach the virtual concentration within 1 hour, and reach the highest concentration after 3 days. The NOEL of 15 mg/kg bw/day may be used as the basis for setting an acceptable daily intake (ADI) for decoquinate. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 0.01 mg/mL
(0.02 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 417.54
Formula

C24H35NO5

CAS No. 18507-89-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCCCOC1=C(C=C2C(=C1)C(=O)C(=CN2)C(=O)OCC)OCC

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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