D-(+)-Trehalose dihydrate

Catalog No.S3992 Batch:S399201

Technical Data

Formula	C₁₂ H₂₂O_{11 . 2}H₂O
Molecular Weight	378.33	CAS No.	6138-23-4
Solubility (25°C)*	In vitro	Water	76 mg/mL (200.88 mM)
		DMSO	75 mg/mL (198.23 mM)

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.
In vitro	Trehalose has been shown to play a key role in various types of stress-tolerance including radiation, cold and dehydration stresses in bacteria, yeast, nematodes, rotifers, tardigrades, certain crustaceans and insects. Studies on the role of trehalose in stress-tolerance suggest that trehalose must be presence on both sides of the cell membrane to confer protection. It is a non-charged and hydrophilic disaccharide which does not freely penetrate the mammalian cell membrane without external interventions^[1].

Description

Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

In vitro

Trehalose has been shown to play a key role in various types of stress-tolerance including radiation, cold and dehydration stresses in bacteria, yeast, nematodes, rotifers, tardigrades, certain crustaceans and insects. Studies on the role of trehalose in stress-tolerance suggest that trehalose must be presence on both sides of the cell membrane to confer protection. It is a non-charged and hydrophilic disaccharide which does not freely penetrate the mammalian cell membrane without external interventions^[1].

Protocol (from reference)

References

[1] Alireza Abazari, et al. PLoS One. 2015, 10(6): e0130323.

Selleck's D-(+)-Trehalose dihydrate has been cited by 2 publications

Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells [ Chem Biol Interact, 2023, 10.1016/j.cbi.2023.110819]	PubMed: 38000454
Solubility enhancement of BCS Class II drug by solid phospholipid dispersions: Spray drying versus freeze-drying. [ Int J Pharm, 2015, 496(2):382-91]	PubMed: 26468038

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.