CAS No. 6138-23-4

Batch: Purity:98
Check CoA
D-(+)-Trehalose dihydrate Chemical Structure
Chemical Structure
Check the D-(+)-Trehalose dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate
CAS Number 6138-23-4
Molecular Formula

C12 H22O11 . 2H2O
Molecular Weight (MW) 378.33
SMILES C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O
InChIKey DPVHGFAJLZWDOC-PVXXTIHASA-N

Ordering Information

Biological Activity

D-(+)-Trehalose dihydrate is a natural non-reducing disaccharide that functions as an mTOR-independent autophagy inducer. It promotes cellular clearance of misfolded and aggregated proteins by stimulating autophagic flux without inhibiting mTOR signaling. This enhancement of autophagic activity protects host cells against protein conformational toxicity and maintains cellular homeostasis during severe metabolic, oxidative, and osmotic stress. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 76 mg/mL
DMSO 75 mg/mL (198.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.