CAS No. 174672-06-1
Batch:
Purity:99.85
Chemical Structure
Check the
AN-2718
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-chloro-1-hydroxy-3H-2,1-benzoxaborole | |
|---|---|---|
| CAS Number | 174672-06-1 | |
| Molecular Formula |
C7H6BClO2 |
|
| Molecular Weight (MW) | 168.39 | |
| SMILES | OB1OCC2=CC(=CC=C12)Cl | |
| InChIKey | HMAFTPZYFJFEHK-UHFFFAOYSA-N |
Biological Activity
AN-2718 is an oxaborole antifungal agent that targets leucyl-tRNA synthetase (LeuRS). It blocks fungal growth by inhibiting protein synthesis through the oxaborole tRNA trapping (OBORT) mechanism. By trapping tRNA in the editing site of LeuRS, AN-2718 prevents aminoacylation and suppresses downstream translation, leading to the inhibition of fungal cell proliferation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(201.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 34 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.