Numerous clinical trials spanning Early Phase 1 through Phase 3 evaluate vorinostat monotherapy and combination regimens across diverse indications, predominantly hematologic malignancies—such as cutaneous T-cell lymphoma, acute myeloid leukemia, and non-Hodgkin lymphoma—as well as solid tumors, HIV-1 infection, and Alzheimer's disease. Sponsored by academic institutions and industry partners including the National Cancer Institute and Merck Sharp & Dohme LLC, this portfolio encompasses active, recruiting, completed, terminated, and withdrawn studies.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03167437 | RECRUITING | Crohn's Disease |
National Institute of Allergy and Infectious Diseases (NIAID) |
2017-10-30 | PHASE1; PHASE2 |
| NCT07261241 | NOT_YET_RECRUITING | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2026-12-31 | PHASE2 |
| NCT02559778 | RECRUITING | Neuroblastoma |
Giselle Sholler |
2015-09 | PHASE2 |
| NCT05848687 | RECRUITING | Lymphoblastic Leukemia |
Tanja Andrea Gruber |
2023-11-03 | PHASE1; PHASE2 |
| NCT06995521 | RECRUITING | GVHD |
Sung Won Choi |
2026-09 | PHASE2 |
| NCT03843528 | ACTIVE_NOT_RECRUITING | Acute Myeloid Leukemia; Myelodysplastic Syndromes; Mixed Phenotype Acute Leukemia; Juvenile Myelomonocytic Leukemia |
Johns Hopkins All Children's Hospital |
2019-05-01 | PHASE1 |
| NCT01297764 | ACTIVE_NOT_RECRUITING | Multiple Myeloma |
Hackensack Meridian Health |
2011-04 | PHASE1; PHASE2 |
| NCT06693284 | RECRUITING | Primary Malignant Peripheral Nerve Sheath Tumors |
University of Minnesota |
2025-11-20 | EARLY_PHASE1 |
| NCT05756660 | SUSPENDED | Ototoxicity, Drug-Induced |
Children's Hospital Medical Center, Cincinnati |
2023-03-01 | EARLY_PHASE1 |
| NCT05317403 | RECRUITING | Acute Myeloid Leukemia, in Relapse; Acute Myeloid Leukemia Refractory |
Medical College of Wisconsin |
2023-03-31 | PHASE1 |
| NCT07150013 | RECRUITING | Rett Syndrome |
Unravel Biosciences, Inc. |
2026-03-15 | PHASE1 |
| NCT00392353 | ACTIVE_NOT_RECRUITING | Acute Erythroid Leukemia; Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Myelodysplastic Syndrome With Ring Sideroblasts; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia |
National Cancer Institute (NCI) |
2006-11-22 | PHASE1; PHASE2 |
| NCT04308330 | RECRUITING | Ewing Sarcoma; Rhabdomyosarcoma; Wilms Tumor; Neuroblastoma; Hepatoblastoma; Germ Cell Tumor |
New York Medical College |
2017-03-17 | PHASE1 |
| NCT07150026 | RECRUITING | Pitt Hopkins Syndrome |
Unravel Biosciences, Inc. |
2026-03-15 | PHASE1 |
| NCT01587352 | ACTIVE_NOT_RECRUITING | Metastatic Uveal Melanoma; Stage IV Uveal Melanoma AJCC v7 |
National Cancer Institute (NCI) |
2012-05-29 | PHASE2 |
| NCT06145633 | RECRUITING | Castration-Resistant Prostate Carcinoma; Metastatic Prostate Adenocarcinoma; Stage IVB Prostate Cancer AJCC v8 |
Fred Hutchinson Cancer Center |
2024-09-18 | PHASE2 |
| NCT07217379 | SUSPENDED | HIV (Human Immunodeficiency Virus) |
University of North Carolina, Chapel Hill |
2025-10-02 | PHASE1 |
| NCT03117751 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; Acute Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
2017-03-29 | PHASE2; PHASE3 |
| NCT01087554 | ACTIVE_NOT_RECRUITING | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-03 | PHASE1 |
| NCT02943642 | WITHDRAWN | Mycosis Fungoides |
Virogen Biotechnology Inc. |
2026-05 | PHASE2 |
| NCT03742245 | ACTIVE_NOT_RECRUITING | Breast Cancer Metastatic; Breast Cancer |
The Methodist Hospital Research Institute |
2019-06-11 | PHASE1 |
| NCT03259503 | COMPLETED | Recurrent Diffuse Large B-Cell Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma |
M.D. Anderson Cancer Center |
2019-09-13 | PHASE1 |
| NCT05608369 | WITHDRAWN | HPV-Related Squamous Cell Carcinoma; Squamous Cell Carcinoma of the Oral Cavity; Squamous Cell Carcinoma of the Larynx; Squamous Cell Carcinoma of the Oropharynx; Squamous Cell Carcinoma of the Hypopharynx |
Case Comprehensive Cancer Center |
2025-06-01 | PHASE2 |
| NCT03842696 | ACTIVE_NOT_RECRUITING | Hematologic Diseases; Acute Leukemia in Remission; Chronic Myelogenous Leukemia - Chronic Phase; Chronic Myelogenous Leukemia, Accelerated Phase; Chronic Myelogenous Leukemia, Blastic Phase; Myelodysplastic Syndromes; Mantle Cell Lymphoma; Follicular Lymphoma; Diffuse Large B Cell Lymphoma; Non Hodgkin Lymphoma; Graft Vs Host Disease; Graft-versus-host-disease |
University of Michigan Rogel Cancer Center |
2020-02-04 | PHASE1; PHASE2 |
| NCT04339751 | WITHDRAWN | Cushing's Disease |
National Institute of Neurological Disorders and Stroke (NINDS) |
2025-04-11 | PHASE2 |
| NCT02420613 | COMPLETED | Diffuse Intrinsic Pontine Glioma |
M.D. Anderson Cancer Center |
2015-10-05 | PHASE1 |
| NCT05700630 | WITHDRAWN | HIV-1-infection; ART; Cd4+ Lymphocyte Deficiency; Lymphoid Tissue; Infection; Interleukin |
Masonic Cancer Center, University of Minnesota |
2024-07-15 | PHASE1 |
| NCT05700630 | Withdrawn | HIV-1-infection|ART|Cd4+ Lymphocyte Deficiency|Lymphoid Tissue; Infection|Interleukin |
Masonic Cancer Center University of Minnesota |
2024-07-15 | Phase 1 |
| NCT03056495 | TERMINATED | Alzheimer Disease |
German Center for Neurodegenerative Diseases (DZNE) |
2017-09-28 | PHASE1 |
| NCT03332667 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2018-09-12 | PHASE1 |
| NCT02638090 | ACTIVE_NOT_RECRUITING | Lung Cancer; Non-small Cell Lung Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2016-03-22 | PHASE1; PHASE2 |
| NCT03561259 | UNKNOWN | Neuroblastoma; Neuroectodermal Tumors; Neoplasms |
Jubilant DraxImage Inc. |
2019-10-21 | PHASE2 |
| NCT02836548 | COMPLETED | Melanoma; Skin Neoplasms |
The Netherlands Cancer Institute |
2016-06 | PHASE1; PHASE2 |
| NCT01236560 | COMPLETED | Brain Stem Glioma; Cerebral Astrocytoma; Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Spinal Cord Neoplasm |
National Cancer Institute (NCI) |
2011-01-26 | PHASE2; PHASE3 |
| NCT03150329 | ACTIVE_NOT_RECRUITING | Grade 3b Follicular Lymphoma; Recurrent B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between DLBCL and Classic HL; Recurrent Classic Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3a Follicular Lymphoma; Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma; Recurrent Transformed Non-Hodgkin Lymphoma; Refractory B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between DLBCL and Classic HL; Refractory Classic Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma; Refractory Transformed Non-Hodgkin Lymphoma |
City of Hope Medical Center |
2017-07-18 | PHASE1 |
| NCT04190056 | TERMINATED | Anatomic Stage IV Breast Cancer AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8 |
University of California, San Francisco |
2021-03-11 | PHASE2 |
| NCT02619253 | COMPLETED | Renal Cell Carcinoma; Urinary Bladder Neoplasms |
Nabil Adra |
2016-02-23 | PHASE1 |
| NCT04357873 | COMPLETED | Squamous Cell Lung Cancer; Vulvar Cancer; Penile Cancer; Cervix Cancer; Head and Neck Squamous Cell Carcinoma; Anal Cancer |
UNICANCER |
2020-10-28 | PHASE2 |
| NCT01608139 | WITHDRAWN | Advanced Cancers |
M.D. Anderson Cancer Center |
2012-11 | PHASE1 |
| NCT03212989 | COMPLETED | HIV-1 Infection |
University of North Carolina, Chapel Hill |
2017-06-27 | PHASE1 |
| NCT02553460 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
2016-01-29 | PHASE1; PHASE2 |
| NCT01554852 | UNKNOWN | Multiple Myeloma |
University of Leeds |
2010-05 | PHASE3 |
| NCT02083250 | COMPLETED | Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission; Allogeneic Hematopoietic Stem Cell Transplantation Recipient; Myelodysplastic Syndrome; Previously Treated Myelodysplastic Syndrome; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia |
M.D. Anderson Cancer Center |
2014-03-06 | PHASE1 |
| NCT04220008 | WITHDRAWN | Recurrent Aggressive Non-Hodgkin Lymphoma; Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Burkitt Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent High Grade B-Cell Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Recurrent Transformed B-Cell Non-Hodgkin Lymphoma |
M.D. Anderson Cancer Center |
2021-10-29 | PHASE2 |
| NCT03426891 | COMPLETED | Glioblastoma; Brain Tumor; GBM |
H. Lee Moffitt Cancer Center and Research Institute |
2018-03-16 | PHASE1 |
| NCT01038388 | COMPLETED | Multiple Myeloma |
Emory University |
2010-01-15 | PHASE1 |
| NCT01879085 | COMPLETED | Sarcoma |
Melissa Burgess, MD |
2013-09-24 | PHASE1; PHASE2 |
| NCT02035137 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2014-07 | PHASE2 |
| NCT01266057 | COMPLETED | Advanced Cancers |
M.D. Anderson Cancer Center |
2011-04-28 | PHASE1 |
| NCT03803605 | COMPLETED | HIV-1 Infection |
University of North Carolina, Chapel Hill |
2019-02-12 | PHASE1 |
| NCT03878524 | TERMINATED | Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid System Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma |
OHSU Knight Cancer Institute |
2020-04-01 | PHASE1 |
| NCT01294670 | COMPLETED | Solid Tumors; Relapsed/Refractory Sarcomas |
Memorial Sloan Kettering Cancer Center |
2011-02-09 | PHASE1; PHASE2 |
| NCT03713320 | TERMINATED | Cutaneous T-Cell Lymphoma/Mycosis Fungoides |
miRagen Therapeutics, Inc. |
2019-04-02 | PHASE2 |
| NCT03263936 | COMPLETED | Acute Myelogenous Leukemia |
Therapeutic Advances in Childhood Leukemia Consortium |
2017-07-11 | PHASE1 |
| NCT02349867 | COMPLETED | Pancreatic Adenocarcinoma; Stage IA Pancreatic Cancer; Stage IB Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer; Stage III Pancreatic Cancer; Recurrent Pancreatic Carcinoma |
Virginia Commonwealth University |
2015-01-29 | PHASE1 |
| NCT00867178 | COMPLETED | Medulloblastoma; Pineoblastoma; Supratentorial Embryonal Tumor, Not Otherwise Specified |
National Cancer Institute (NCI) |
2009-02-25 | PHASE1 |
| NCT03894826 | UNKNOWN | Refractory Epilepsy |
University of Calgary |
2018-12-10 | PHASE2 |
| NCT03022565 | WITHDRAWN | Uveal Melanoma |
University of Miami |
2020-01 | EARLY_PHASE1 |
| NCT00555399 | TERMINATED | Glioblastoma Multiforme; Anaplastic Glioma |
M.D. Anderson Cancer Center |
2007-11-28 | PHASE1; PHASE2 |
| NCT02042989 | COMPLETED | Advanced Cancers |
M.D. Anderson Cancer Center |
2014-06-27 | PHASE1 |
| NCT03022565 | Withdrawn | Uveal Melanoma |
University of Miami|University of Miami Sylvester Comprehensive Cancer Center |
2020-01 | Early Phase 1 |
| NCT00729118 | COMPLETED | Multiple Myeloma; Plasma Cell Neoplasm |
Ohio State University Comprehensive Cancer Center |
2008-09-26 | PHASE1 |
| NCT02538510 | COMPLETED | Head and Neck Squamous Cell Carcinoma; Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Recurrent Nasopharynx Carcinoma; Recurrent Salivary Gland Carcinoma; Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary; Stage III Major Salivary Gland Carcinoma; Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage III Nasopharyngeal Carcinoma; Stage IV Nasopharyngeal Carcinoma; Stage IVA Major Salivary Gland Carcinoma; Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage IVB Major Salivary Gland Carcinoma; Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage IVC Major Salivary Gland Carcinoma; Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma |
University of Washington |
2015-10-08 | PHASE1; PHASE2 |
| NCT02395627 | TERMINATED | Breast Neoplasms |
University of California, San Francisco |
2015-05-04 | PHASE2 |
| NCT03198559 | TERMINATED | HIV Infections |
University of Melbourne |
2017-08-08 | PHASE1; PHASE2 |
| NCT02589145 | TERMINATED | Lymphoma |
M.D. Anderson Cancer Center |
2016-06-22 | PHASE1; PHASE2 |
| NCT03509207 | TERMINATED | Leiomyosarcoma; Endometrial Stromal Tumors; Carcinosarcomas Uterine |
Medical University of Graz |
2017-12-14 | PHASE2 |
| NCT03263533 | WITHDRAWN | Schizophrenia |
Virginia Commonwealth University |
2017-04 | EARLY_PHASE1 |
| NCT03050450 | TERMINATED | Central Nervous System Tumors |
Johns Hopkins All Children's Hospital |
2016-08-10 | PHASE1 |
| NCT03382834 | COMPLETED | HIV Infections |
National Institute of Allergy and Infectious Diseases (NIAID) |
2018-04-26 | PHASE2 |
| NCT01593670 | COMPLETED | Myelodysplastic Syndrome |
Masonic Cancer Center, University of Minnesota |
2013-03 | PHASE2 |
| NCT00268385 | ACTIVE_NOT_RECRUITING | Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Recurrent Adult Brain Neoplasm |
National Cancer Institute (NCI) |
2005-12-16 | PHASE1 |
| NCT02108002 | COMPLETED | Von Hippel-Lindau Disease |
National Institute of Neurological Disorders and Stroke (NINDS) |
2014-04-05 | PHASE1 |
| NCT02114502 | WITHDRAWN | Myeloma |
M.D. Anderson Cancer Center |
2014-09 | PHASE2 |
| NCT02707900 | TERMINATED | HIV-1 Infection |
University of North Carolina, Chapel Hill |
2016-03 | PHASE1 |
| NCT01175980 | COMPLETED | Recurrent Oral Cavity Adenoid Cystic Carcinoma; Recurrent Salivary Gland Carcinoma; Salivary Gland Adenoid Cystic Carcinoma; Stage III Major Salivary Gland Cancer AJCC v7; Stage III Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7; Stage IVA Major Salivary Gland Cancer AJCC v7; Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7; Stage IVB Major Salivary Gland Cancer AJCC v7; Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7; Stage IVC Major Salivary Gland Cancer AJCC v7; Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7; Tongue Carcinoma |
National Cancer Institute (NCI) |
2010-08-06 | PHASE2 |
| NCT01567709 | COMPLETED | Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Primary Cutaneous B-Cell Non-Hodgkin Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Non-Hodgkin Lymphoma; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia |
National Cancer Institute (NCI) |
2012-04-16 | PHASE1 |
| NCT02316340 | COMPLETED | Colorectal Cancer |
The University of Texas Health Science Center at San Antonio |
2015-02-11 | PHASE2 |
| NCT02151721 | UNKNOWN | Non-Small-Cell Lung Carcinoma |
Kanazawa University |
2014-06-01 | PHASE1 |
| NCT01023737 | COMPLETED | Malignant Solid Tumour |
The University of Texas Health Science Center at San Antonio |
2009-11 | PHASE1 |
| NCT00703664 | COMPLETED | Recurrent Mantle Cell Lymphoma; Recurrent Non-Hodgkin Lymphoma |
National Cancer Institute (NCI) |
2008-07-09 | PHASE2 |
| NCT01983969 | COMPLETED | Advanced Cancers; Lymphoma |
M.D. Anderson Cancer Center |
2013-11-07 | PHASE1; PHASE2 |
| NCT02336074 | COMPLETED | HIV |
Imperial College London |
2015-11-27 | PHASE2 |
| NCT01064921 | COMPLETED | Stage III Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx |
Ohio State University Comprehensive Cancer Center |
2010-01-19 | PHASE1 |
| NCT03167437 | Recruiting | Crohn''s Disease |
National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
2017-10-30 | Phase 1|Phase 2 |
| NCT03056495 | Terminated | Alzheimer Disease |
German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen |
2017-09-28 | Phase 1 |
| NCT01189266 | COMPLETED | Anaplastic Astrocytoma; Anaplastic Oligoastrocytoma; Diffuse Intrinsic Pontine Glioma; Gliosarcoma |
National Cancer Institute (NCI) |
2010-08-09 | PHASE1; PHASE2 |
| NCT02412475 | TERMINATED | Leukemia, Acute Myeloid |
Michael Burke |
2015-02-21 | PHASE1 |
| NCT01802333 | COMPLETED | Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2013-02-12 | PHASE3 |
| NCT00720876 | COMPLETED | Lymphoma |
City of Hope Medical Center |
2008-07-23 | PHASE2 |
| NCT01339871 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2011-04-20 | PHASE1 |
| NCT01422499 | COMPLETED | Children With Relapsed Solid Tumor, Lymphoma or Leukemia |
National Center for Tumor Diseases, Heidelberg |
2012-03 | PHASE1; PHASE2 |
| NCT01728805 | COMPLETED | Cutaneous T-Cell Lymphoma |
Kyowa Kirin, Inc. |
2012-11 | PHASE3 |
| NCT01075113 | COMPLETED | Liver Cancer |
Virginia Commonwealth University |
2010-08-10 | PHASE1 |
| NCT00667615 | COMPLETED | Hodgkin's Disease; Lymphoma |
Memorial Sloan Kettering Cancer Center |
2008-04 | PHASE1; PHASE2 |
| NCT01790568 | COMPLETED | Graft vs Host Disease; Hematologic Neoplasms; Non-Neoplastic Hematologic and Lymphocytic Disorder |
University of Michigan Rogel Cancer Center |
2014-12 | PHASE2 |
| NCT02419755 | TERMINATED | Mixed Lineage Acute Leukemia; Acute Myeloid Leukemia; Acute Lymphoid Leukemia |
St. Jude Children's Research Hospital |
2015-04-14 | PHASE2 |
| NCT02124083 | COMPLETED | Neimann-Pick Disease |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
2014-04-25 | PHASE1; PHASE2 |
| NCT01193842 | COMPLETED | AIDS-Related Plasmablastic Lymphoma; AIDS-Related Primary Effusion Lymphoma; Ann Arbor Stage I Diffuse Large B-Cell Lymphoma; Ann Arbor Stage I Grade 3 Follicular Lymphoma; Ann Arbor Stage II Diffuse Large B-Cell Lymphoma; Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma; Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma; Ann Arbor Stage III Diffuse Large B-Cell Lymphoma; Ann Arbor Stage III Grade 3 Follicular Lymphoma; Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma; Ann Arbor Stage IV Grade 3 Follicular Lymphoma; HIV Infection; Plasmablastic Lymphoma; Primary Effusion Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Grade 3 Follicular Lymphoma |
National Cancer Institute (NCI) |
2010-10-06 | PHASE1; PHASE2 |
| NCT00918723 | COMPLETED | Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Small Lymphocytic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Small Lymphocytic Lymphoma |
Fred Hutchinson Cancer Center |
2009-06 | PHASE1; PHASE2 |
| NCT01534260 | COMPLETED | Acute Myeloid Leukemia |
Hamid Sayar |
2012-02-10 | PHASE1; PHASE2 |
| NCT00253630 | COMPLETED | Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Nodal Marginal Zone Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma |
National Cancer Institute (NCI) |
2005-09 | PHASE2 |
| NCT00702572 | TERMINATED | Non-small Cell Lung Cancer |
Milton S. Hershey Medical Center |
2008-04 | PHASE1 |
| NCT01249443 | TERMINATED | HIV Infection; Recurrent Anal Cancer; Recurrent Breast Cancer; Recurrent Esophageal Cancer; Recurrent Gastric Cancer; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage IV Anal Cancer; Stage IV Breast Cancer; Stage IV Esophageal Cancer; Stage IV Gastric Cancer; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Unspecified Adult Solid Tumor, Protocol Specific |
AIDS Malignancy Consortium |
2013-11 | PHASE1 |
| NCT01319383 | COMPLETED | HIV-1 Infection |
University of North Carolina, Chapel Hill |
2011-02 | PHASE1; PHASE2 |
| NCT01617226 | COMPLETED | Leukemia, Myeloid, Acute |
University of Birmingham |
2012-09 | PHASE2 |
| NCT01045538 | COMPLETED | Gastric Cancer; Histone Deacetylase Inhibitor |
Asan Medical Center |
2010-02 | PHASE1; PHASE2 |
| NCT00972478 | ACTIVE_NOT_RECRUITING | Ann Arbor Stage II Non-Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma |
National Cancer Institute (NCI) |
2010-11-15 | PHASE1; PHASE2 |
| NCT01394354 | COMPLETED | Multiple Myeloma in Relapse |
University Hospital Freiburg |
2011-08 | PHASE1; PHASE2 |
| NCT01502085 | COMPLETED | Multiple Myeloma |
Hackensack Meridian Health |
2011-12 | PHASE1; PHASE2 |
| NCT02475915 | COMPLETED | Acute HIV Infection |
SEARCH Research Foundation |
2015-01 | PHASE1; PHASE2 |
| NCT01421173 | COMPLETED | Lymphoma |
M.D. Anderson Cancer Center |
2011-08 | PHASE1 |
| NCT01578343 | TERMINATED | Mantle Cell Lymphoma |
Samsung Medical Center |
2012-06 | PHASE2 |
| NCT01174199 | TERMINATED | Prostate Cancer; Adenocarcinoma of the Prostate; Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer |
Roswell Park Cancer Institute |
2012-02 | PHASE1 |
| NCT01720875 | COMPLETED | Multiple Myeloma |
University of Leeds |
2013-08-09 | PHASE2 |
| NCT01483690 | TERMINATED | Acute Lymphoblastic Leukemia; Precursor B-Cell Lymphoblastic Leukemia; Precursor T-Cell Lymphoblastic Leukemia |
Therapeutic Advances in Childhood Leukemia Consortium |
2011-12 | PHASE1; PHASE2 |
| NCT01059552 | COMPLETED | Locally Advanced Non-small Cell Lung Cancer |
Fox Chase Cancer Center |
2009-12-16 | PHASE1 |
| NCT01266031 | COMPLETED | Malignant Glioma; Recurrent Glioblastoma |
National Cancer Institute (NCI) |
2011-07-12 | PHASE1; PHASE2 |
| NCT00992446 | COMPLETED | Adult Diffuse Large B-Cell Lymphoma; B-Cell Non-Hodgkin Lymphoma; Follicular Lymphoma; Mantle Cell Lymphoma; Non-Hodgkin Lymphoma; T-Cell Non-Hodgkin Lymphoma |
Fred Hutchinson Cancer Center |
2010-09-02 | PHASE2 |
| NCT01522976 | ACTIVE_NOT_RECRUITING | Chronic Myelomonocytic Leukemia; Chronic Myelomonocytic Leukemia-1; Chronic Myelomonocytic Leukemia-2; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome/Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2012-03-01 | PHASE2 |
| NCT01267240 | TERMINATED | Paranasal Sinus Squamous Cell Carcinoma; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral Cavity Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Stage IVA Hypopharyngeal Squamous Cell Carcinoma; Stage IVA Laryngeal Squamous Cell Carcinoma; Stage IVA Oral Cavity Squamous Cell Carcinoma; Stage IVA Oropharyngeal Squamous Cell Carcinoma; Stage IVB Hypopharyngeal Squamous Cell Carcinoma; Stage IVB Laryngeal Squamous Cell Carcinoma; Stage IVB Oral Cavity Squamous Cell Carcinoma; Stage IVB Oropharyngeal Squamous Cell Carcinoma; Stage IVC Hypopharyngeal Squamous Cell Carcinoma; Stage IVC Laryngeal Squamous Cell Carcinoma; Stage IVC Oral Cavity Squamous Cell Carcinoma; Stage IVC Oropharyngeal Squamous Cell Carcinoma |
National Cancer Institute (NCI) |
2010-12 | PHASE2 |
| NCT00948064 | COMPLETED | Leukemia |
M.D. Anderson Cancer Center |
2009-09-08 | PHASE2 |
| NCT01720602 | COMPLETED | Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer |
University of Washington |
2012-11 | |
| NCT00416130 | UNKNOWN | Breast Cancer |
National University Hospital, Singapore |
2007-01 | PHASE1; PHASE2 |
| NCT00764517 | COMPLETED | Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Chronic Lymphocytic Leukemia; Recurrent Indolent Adult Non-Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma |
OHSU Knight Cancer Institute |
2008-08 | PHASE2 |
| NCT01492881 | WITHDRAWN | Multiple Myeloma |
UNC Lineberger Comprehensive Cancer Center |
2012-04 | PHASE2 |
| NCT01738646 | COMPLETED | Recurrent Glioblastoma Multiforme; Malignant Glioma; Adult Brain Tumor |
Duke University |
2013-01 | PHASE2 |
| NCT01019850 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2010-03 | PHASE1 |
| NCT01550224 | COMPLETED | Acute Myeloid Leukemia With 11q23-abnormality in Relapse |
Steven E. Coutre |
2013-05-01 | PHASE2 |
| NCT01000155 | TERMINATED | Sickle Cell Disease; Sickle Cell Anemia |
Dana-Farber Cancer Institute |
2009-10 | PHASE2 |
| NCT01695057 | WITHDRAWN | Stage II Breast Cancer; Stage IIIA Breast Cancer; Triple-negative Breast Cancer |
University of Southern California |
2012-10 | |
| NCT01208454 | COMPLETED | Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
National Cancer Institute (NCI) |
2010-12 | PHASE1 |
| NCT00946673 | COMPLETED | Brain Cancer; Neoplasm Metastasis; Lung Cancer; Carcinoma, Non-Small-Cell Lung |
Stanford University |
2009-06 | PHASE1 |
| NCT01110876 | TERMINATED | Brain Cancer; Glioblastoma Multiforme |
M.D. Anderson Cancer Center |
2011-06 | PHASE1; PHASE2 |
| NCT00616967 | ACTIVE_NOT_RECRUITING | Breast Cancer |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2008-05 | PHASE2 |
| NCT00574587 | COMPLETED | Breast Cancer |
Albert Einstein College of Medicine |
2007-12 | PHASE1; PHASE2 |
| NCT01281176 | ACTIVE_NOT_RECRUITING | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2011-02-09 | PHASE1 |
| NCT01169532 | COMPLETED | Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific |
Fox Chase Cancer Center |
2010-10 | PHASE1 |
| NCT01789255 | COMPLETED | Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Graft Versus Host Disease; Intraocular Lymphoma; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Ringed Sideroblasts; Refractory Chronic Lymphocytic Leukemia; Refractory Cytopenia With Multilineage Dysplasia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Central Nervous System Hodgkin Lymphoma; Secondary Central Nervous System Non-Hodgkin Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia |
National Cancer Institute (NCI) |
2013-06 | PHASE2 |
| NCT00731731 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma |
National Cancer Institute (NCI) |
2009-07-10 | PHASE1; PHASE2 |
| NCT00656617 | COMPLETED | Acute Myeloid Leukemia (AML); Myelodysplastic Syndrome (MDS) |
M.D. Anderson Cancer Center |
2008-04 | PHASE2 |
| NCT00691210 | COMPLETED | Hodgkin's Disease; Non-Hodgkin's Lymphoma |
Columbia University |
2008-06 | PHASE1 |
| NCT01600742 | TERMINATED | Brain Metastasis |
National Taiwan University Hospital |
2012-08 | PHASE2 |
| NCT01027676 | UNKNOWN | Non-Small-Cell Lung Carcinoma |
National Cancer Center, Korea |
2010-06 | PHASE1; PHASE2 |
| NCT01748240 | TERMINATED | Myelodysplastic Syndrome |
Groupe Francophone des Myelodysplasies |
2013-03 | PHASE2 |
| NCT00918489 | COMPLETED | Soft Tissue Sarcoma |
Heidelberg University |
2010-05 | PHASE2 |
| NCT01378481 | TERMINATED | Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Recurrent Adult Brain Neoplasm |
National Cancer Institute (NCI) |
2012-06 | PHASE1 |
| NCT01187446 | TERMINATED | Cutaneous Lymphoma; Cutaneous T-cell Lymphoma |
Stanford University |
2010-12 | PHASE1; PHASE2 |
| NCT01276717 | COMPLETED | Lymphoma |
University of Rochester |
2011-01 | PHASE1 |
| NCT00762255 | COMPLETED | Glioblastoma |
H. Lee Moffitt Cancer Center and Research Institute |
2008-09 | PHASE1 |
| NCT00895934 | COMPLETED | Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2009-05 | PHASE1; PHASE2 |
| NCT00719875 | COMPLETED | Advanced Breast Cancer |
Yale University |
2008-12 | PHASE1 |
| NCT00324870 | COMPLETED | Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer |
National Cancer Institute (NCI) |
2006-02 | PHASE1; PHASE2 |
| NCT01500538 | TERMINATED | Follicular Lymphoma; Marginal Zone Lymphoma; Mantle Cell Lymphoma |
Peter MacCallum Cancer Centre, Australia |
2012-10 | PHASE2 |
| NCT00336063 | ACTIVE_NOT_RECRUITING | Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma; Recurrent Nasopharyngeal Undifferentiated Carcinoma; Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7; Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7 |
National Cancer Institute (NCI) |
2006-03-03 | PHASE1 |
| NCT01413750 | TERMINATED | Stage IIIA Lung Non-Small Cell Cancer AJCC v7; Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Lung Non-Small Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
2010-11-08 | PHASE2 |
| NCT00810602 | COMPLETED | Hematologic Malignancies; Graft vs Host Disease |
Pavan Reddy, MD |
2009-01 | PHASE1; PHASE2 |
| NCT01120834 | COMPLETED | Lymphoma |
Weill Medical College of Cornell University |
2010-09 | PHASE1; PHASE2 |
| NCT00983268 | COMPLETED | Pancreatic Cancer; Periampullary Adenocarcinoma |
Vanderbilt-Ingram Cancer Center |
2009-10 | PHASE1 |
| NCT00958074 | TERMINATED | Cutaneous T-cell Lymphoma Stage I; Cutaneous T-cell Lymphoma Stage II; Cutaneous T-cell Lymphoma Stage III; Cutaneous T-cell Lymphoma Stage IV |
University of Washington |
2009-07 | PHASE2 |
| NCT00910000 | TERMINATED | Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer |
Dana-Farber Cancer Institute |
2009-06 | PHASE1; PHASE2 |
| NCT01312818 | TERMINATED | Acute Lymphoblastic Leukemia |
Masonic Cancer Center, University of Minnesota |
2011-06 | PHASE2 |
| NCT00882206 | TERMINATED | Leukemia; Lymphoma |
Masonic Cancer Center, University of Minnesota |
2009-04 | PHASE2 |
| NCT00731952 | COMPLETED | Non Small Cell Lung Cancer |
University of Virginia |
2006-06 | PHASE1 |
| NCT00787527 | COMPLETED | Lymphoma |
M.D. Anderson Cancer Center |
2008-11 | PHASE1; PHASE2 |
| NCT01130506 | COMPLETED | Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2010-05-17 | PHASE1 |
| NCT01084057 | COMPLETED | Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer |
City of Hope Medical Center |
2010-05-17 | PHASE1 |
| NCT00561418 | COMPLETED | Lymphoma; Small Intestine Cancer |
Ohio State University Comprehensive Cancer Center |
2007-11 | PHASE1 |
| NCT00798720 | COMPLETED | Carcinoma, Non Small Cell Lung |
University of Wisconsin, Madison |
2008-12 | PHASE2 |
| NCT00537121 | COMPLETED | Esophageal Cancer; Gastric Cancer; Liver Cancer |
Roswell Park Cancer Institute |
2006-11 | PHASE1 |
| NCT01118975 | TERMINATED | Breast Cancer; Neoplasm Metastasis |
University of Maryland, Baltimore |
2010-03 | PHASE1; PHASE2 |
| NCT01076530 | COMPLETED | Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Low-grade Cerebellar Astrocytoma; Childhood Low-grade Cerebral Astrocytoma; Childhood Medulloepithelioma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Extra-adrenal Paraganglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Spinal Cord Neoplasm; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma |
National Cancer Institute (NCI) |
2010-02 | PHASE1 |
| NCT00642954 | COMPLETED | Relapsed or Refractory Multiple Myeloma |
Merck Sharp & Dohme LLC |
2008-02-13 | PHASE1 |
| NCT00839956 | COMPLETED | DS Stage I Plasma Cell Myeloma; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma |
Fred Hutchinson Cancer Center |
2009-02 | PHASE2 |
| NCT01153672 | COMPLETED | Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer |
University of Washington |
2010-11 | |
| NCT00735826 | COMPLETED | Aerodigestive Tract Cancer; Lung Cancer; Esophageal Cancer; Head and Neck Cancer |
Dartmouth-Hitchcock Medical Center |
2009-03 | |
| NCT00821951 | COMPLETED | Non-Small Cell Lung Cancer (NSCLC) |
Yale University |
2009-05 | PHASE1 |
| NCT00972842 | TERMINATED | Peripheral T-Cell Non-Hodgkin's Lymphoma |
Arbeitsgemeinschaft medikamentoese Tumortherapie |
2009-09 | PHASE1; PHASE2 |
| NCT00702962 | TERMINATED | Small Cell Lung Cancer |
Milton S. Hershey Medical Center |
2008-09 | PHASE1; PHASE2 |
| NCT00948688 | TERMINATED | Pancreatic Cancer; Adenocarcinoma of the Pancreas |
Massachusetts General Hospital |
2009-08 | PHASE1; PHASE2 |
| NCT00976183 | TERMINATED | Ovarian Neoplasms |
Gynecologic Oncology Associates |
2009-10 | PHASE1; PHASE2 |
| NCT00331955 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2006-03 | PHASE1 |
| NCT00818649 | TERMINATED | Leukemia; Myelodysplastic Syndrome |
Masonic Cancer Center, University of Minnesota |
2009-01 | PHASE2 |
| NCT01342757 | COMPLETED | Adult Glioblastoma; Depression; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2010-12 | |
| NCT00837174 | WITHDRAWN | Non-Hodgkin Lymphoma |
The Methodist Hospital Research Institute |
2010-06 | PHASE2 |
| NCT00127140 | COMPLETED | Lymphoma |
Merck Sharp & Dohme LLC |
2005-06 | PHASE1 |
| NCT00857324 | TERMINATED | Multiple Myeloma |
Tiziana Marangon |
2009-03 | PHASE1; PHASE2 |
| NCT00939991 | COMPLETED | Brain Tumor; Glioblastoma |
Katy Peters |
2009-10 | PHASE1; PHASE2 |
| NCT01501370 | WITHDRAWN | Multiple Myeloma |
Tiziana Marangon |
2012-01 | PHASE2 |
| NCT00838929 | COMPLETED | Brain Metastases |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2009-03 | PHASE1 |
| NCT00503971 | TERMINATED | Non-small Cell Lung Cancer |
Spanish Lung Cancer Group |
2008-05 | PHASE1; PHASE2 |
| NCT00744354 | TERMINATED | Multiple Myeloma and Plasma Cell Neoplasm |
UNC Lineberger Comprehensive Cancer Center |
2008-10 | PHASE1 |
| NCT00368875 | COMPLETED | Male Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer |
National Cancer Institute (NCI) |
2006-07 | PHASE1; PHASE2 |
| NCT01365065 | UNKNOWN | HIV Positive |
Bayside Health |
2011-05 | PHASE2 |
| NCT00788112 | COMPLETED | Breast Cancer |
University of California, San Francisco |
2009-07 | PHASE1 |
| NCT01194427 | TERMINATED | Stage I Breast Cancer; Stage II Breast Cancer; Stage III Breast Cancer; Invasive Breast Cancer |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2011-03 | PHASE2 |
| NCT00776503 | COMPLETED | Myelodysplastic Syndromes |
Groupe Francophone des Myelodysplasies |
2008-05 | PHASE1; PHASE2 |
| NCT00357305 | COMPLETED | Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Polycythemia Vera; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes |
National Cancer Institute (NCI) |
2006-05 | PHASE1 |
| NCT00635791 | COMPLETED | Malignant Solid Tumour; Renal Cell Carcinoma; Non Small Cell Lung Carcinoma |
University of Colorado, Denver |
2008-03 | PHASE1 |
| NCT00773747 | COMPLETED | Multiple Myeloma |
Merck Sharp & Dohme LLC |
2008-12-01 | PHASE3 |
| NCT00875056 | COMPLETED | Lymphoma |
Merck Sharp & Dohme LLC |
2009-04-15 | PHASE2 |
| NCT00785798 | TERMINATED | Relapsed Lymphomas; Refractory Lymphomas |
Yale University |
2009-01 | PHASE1; PHASE2 |
| NCT00138177 | COMPLETED | Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage III Colon Cancer; Stage III Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-07 | PHASE1 |
| NCT00499811 | COMPLETED | Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia |
National Cancer Institute (NCI) |
2007-06 | PHASE1 |
| NCT00243100 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-11 | PHASE1 |
| NCT00128102 | COMPLETED | Mesothelioma; Lung Cancer |
Merck Sharp & Dohme LLC |
2005-06-30 | PHASE3 |
| NCT00994500 | COMPLETED | Childhood Burkitt Lymphoma; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Childhood Choroid Plexus Tumor; Childhood Craniopharyngioma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Medulloepithelioma; Childhood Meningioma; Childhood Mixed Glioma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Childhood Oligodendroglioma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2009-08 | PHASE1 |
| NCT00771472 | COMPLETED | Lymphoma |
Merck Sharp & Dohme LLC |
2008-08 | PHASE1 |
| NCT00816283 | COMPLETED | Leukemia |
City of Hope Medical Center |
2008-09 | PHASE1 |
| NCT00773838 | COMPLETED | Relapsed or Refractory Multiple Myeloma |
Merck Sharp & Dohme LLC |
2008-12-01 | PHASE2 |
| NCT00942266 | COMPLETED | Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer |
Roswell Park Cancer Institute |
2009-07 | PHASE2 |
| NCT01132911 | COMPLETED | Lymphoma; Sarcoma; WilmsTumor; Neuroblastoma |
National Cancer Institute (NCI) |
2010-05-10 | PHASE1 |
| NCT00365599 | COMPLETED | Breast Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2006-02 | PHASE2 |
| NCT00324740 | TERMINATED | Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer |
National Cancer Institute (NCI) |
2006-03 | PHASE1; PHASE2 |
| NCT00363883 | TERMINATED | Localized Transitional Cell Cancer of the Renal Pelvis and Ureter; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Transitional Cell Carcinoma of the Bladder |
National Cancer Institute (NCI) |
2006-06 | PHASE2 |
| NCT00831493 | TERMINATED | Pancreatic Cancer |
M.D. Anderson Cancer Center |
2009-05 | PHASE1; PHASE2 |
| NCT00937495 | COMPLETED | Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma |
National Cancer Institute (NCI) |
2009-06 | PHASE2 |
| NCT00673153 | TERMINATED | Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Untreated Adult Acute Myeloid Leukemia |
Fred Hutchinson Cancer Center |
2008-03 | PHASE2 |
| NCT00258349 | COMPLETED | Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer |
National Cancer Institute (NCI) |
2006-08 | PHASE1; PHASE2 |
| NCT00791011 | COMPLETED | Hodgkin's Lymphoma; Low Grade Lymphoma; Lymphoma; Mantle Cell Lymphoma; Non-Hodgkin's Lymphoma; Diffuse Large Cell Lymphoma |
Amgen |
2008-02 | PHASE1 |
| NCT01116154 | TERMINATED | Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia |
City of Hope Medical Center |
2010-05 | PHASE1 |
| NCT00641706 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2008-07 | PHASE2 |
| NCT00858234 | COMPLETED | Multiple Myeloma |
Merck Sharp & Dohme LLC |
2009-02-13 | PHASE1 |
| NCT00589472 | COMPLETED | Prostate Adenocarcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer |
National Cancer Institute (NCI) |
2007-11 | PHASE2 |
| NCT00227513 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-07 | PHASE1 |
| NCT00907738 | COMPLETED | Advanced Cancer |
Merck Sharp & Dohme LLC |
2005-08 | PHASE2 |
| NCT00601718 | COMPLETED | Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Waldenström Macroglobulinemia |
University of Washington |
2007-12 | PHASE1; PHASE2 |
| NCT00875745 | COMPLETED | Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes |
Indiana University |
2009-04 | PHASE1 |
| NCT00479232 | COMPLETED | Leukemia, Myelocytic, Acute Myelodysplastic Syndromes; Myelodysplastic Syndromes |
Merck Sharp & Dohme LLC |
2007-06 | PHASE1 |
| NCT00810576 | TERMINATED | Lymphoma |
M.D. Anderson Cancer Center |
2009-01 | PHASE2 |
| NCT00423449 | COMPLETED | Non-Small Cell Lung Cancer |
Merck Sharp & Dohme LLC |
2007-03 | PHASE1 |
| NCT00278395 | COMPLETED | Recurrent Renal Cell Carcinoma; Stage IV Renal Cell Cancer |
National Cancer Institute (NCI) |
2005-10 | PHASE2 |
| NCT00331513 | COMPLETED | Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Blastic Phase Chronic Myelogenous Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes |
National Cancer Institute (NCI) |
2006-03 | PHASE1 |
| NCT00662311 | TERMINATED | Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer |
University of Washington |
2008-03 | PHASE1; PHASE2 |
| NCT00667082 | COMPLETED | Non-Small Cell Lung Cancer; Pancreatic Cancer; Melanoma; Lymphoma; Multiple Myeloma |
Celgene |
2008-03 | PHASE1 |
| NCT00111813 | COMPLETED | Multiple Myeloma |
Merck Sharp & Dohme LLC |
2005-09 | PHASE1 |
| NCT00275080 | COMPLETED | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Secondary Acute Myeloid Leukemia; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2006-02 | PHASE1 |
| NCT00801151 | TERMINATED | Malignant Solid Tumour |
Institut Claudius Regaud |
2009-01 | PHASE1 |
| NCT00357708 | COMPLETED | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Chronic Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Philadelphia Chromosome Negative Chronic Myelogenous Leukemia; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Relapsing Chronic Myelogenous Leukemia |
National Cancer Institute (NCI) |
2006-06 | PHASE1 |
| NCT00278330 | COMPLETED | Blastic Phase Chronic Myelogenous Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Relapsing Chronic Myelogenous Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2006-01 | PHASE1 |
| NCT00697476 | TERMINATED | Small Cell Lung Cancer |
Armando Santoro, MD |
2009-01 | PHASE1; PHASE2 |
| NCT00217412 | COMPLETED | Childhood Acute Promyelocytic Leukemia (M3); Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Juvenile Myelomonocytic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Neuroblastoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Relapsing Chronic Myelogenous Leukemia; Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-08 | PHASE1 |
| NCT00330161 | COMPLETED | Recurrent Prostate Cancer; Stage IV Prostate Cancer |
National Cancer Institute (NCI) |
2006-03 | PHASE2 |
| NCT00127127 | COMPLETED | Tumors |
Merck Sharp & Dohme LLC |
2005-06-10 | PHASE1 |
| NCT00121277 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
University Health Network, Toronto |
2005-09 | PHASE1 |
| NCT00486720 | TERMINATED | Myelodysplastic Syndromes; Blood Disease; Bone Marrow Disease |
Merck Sharp & Dohme LLC |
2007-06 | PHASE2 |
| NCT00481078 | COMPLETED | Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer |
National Cancer Institute (NCI) |
2007-05 | PHASE2 |
| NCT00772798 | UNKNOWN | Ovarian Cancer |
Herlev Hospital |
2007-06 | PHASE2 |
| NCT00132028 | COMPLETED | Adult Favorable Prognosis Hodgkin Lymphoma; Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Adult Unfavorable Prognosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma |
National Cancer Institute (NCI) |
2005-09 | PHASE2 |
| NCT00305773 | COMPLETED | Adult Acute Erythroid Leukemia (M6); Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Refractory Cytopenia With Multilineage Dysplasia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2006-01 | PHASE2 |
| NCT00324480 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2006-03 | PHASE1 |
| NCT00336141 | COMPLETED | Colorectal Cancer |
University of Southern California |
2006-06 | PHASE1 |
| NCT00121225 | COMPLETED | Ciliary Body and Choroid Melanoma, Medium/Large Size; Extraocular Extension Melanoma; Iris Melanoma; Uveal Melanoma; Recurrent Intraocular Melanoma; Recurrent Melanoma; Stage IV Melanoma |
National Cancer Institute (NCI) |
2005-09 | PHASE2 |
| NCT00455351 | COMPLETED | Pelvic Cancer; Radiotherapy |
Oslo University Hospital |
2007-02 | PHASE1 |
| NCT00134043 | COMPLETED | Insular Thyroid Cancer; Recurrent Thyroid Cancer; Stage II Follicular Thyroid Cancer; Stage II Papillary Thyroid Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Papillary Thyroid Cancer; Thyroid Gland Medullary Carcinoma |
National Cancer Institute (NCI) |
2005-12 | PHASE2 |
| NCT00473889 | TERMINATED | Stage IIIB or IV Non-Small Cell Lung Cancer |
Merck Sharp & Dohme LLC |
2007-05 | PHASE2; PHASE3 |
| NCT00138203 | COMPLETED | Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer |
National Cancer Institute (NCI) |
2005-06 | PHASE2 |
| NCT00565227 | TERMINATED | Non-Small-Cell Lung Carcinoma; Prostate Cancer; Bladder Cancer; Urothelial Carcinoma |
University of Michigan Rogel Cancer Center |
2007-04 | PHASE1 |
| NCT00127101 | TERMINATED | Lymphoma |
Merck Sharp & Dohme LLC |
2005-09 | PHASE1 |
| NCT00262834 | COMPLETED | Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage III Breast Cancer |
National Cancer Institute (NCI) |
2005-10 | PHASE2 |
| NCT00238303 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2005-09 | PHASE2 |
| NCT00632931 | COMPLETED | Advanced Cancer Relapsed; Advanced Cancer Refractory |
Merck Sharp & Dohme LLC |
2007-07 | PHASE1 |
| NCT00310024 | COMPLETED | Refractory Multiple Myeloma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma |
National Cancer Institute (NCI) |
2005-11 | PHASE1 |
| NCT00132002 | TERMINATED | Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer |
National Cancer Institute (NCI) |
2005-06 | PHASE2 |
| NCT00106626 | COMPLETED | Advanced Cancer |
Merck Sharp & Dohme LLC |
2005-08 | PHASE1 |
| NCT00251589 | TERMINATED | Carcinoma, Non-Small-Cell Lung |
Merck Sharp & Dohme LLC |
2006-01 | PHASE1; PHASE2 |
| NCT00373490 | COMPLETED | Tumors |
Merck Sharp & Dohme LLC |
2006-07 | PHASE1 |
| NCT00287937 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-07 | PHASE1 |
| NCT00424775 | TERMINATED | Neoplasms |
Merck Sharp & Dohme LLC |
2007-01 | PHASE1 |
| NCT00132067 | COMPLETED | Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
2005-10 | PHASE2 |
| NCT00097929 | COMPLETED | B-cell Lymphoma |
Merck Sharp & Dohme LLC |
2005-05-01 | PHASE2 |
| NCT00109109 | TERMINATED | Multiple Myeloma |
Merck Sharp & Dohme LLC |
2003-12-01 | PHASE1 |
| NCT00045006 | COMPLETED | Cancer |
Memorial Sloan Kettering Cancer Center |
2001-07 | PHASE1 |
| NCT00091559 | COMPLETED | Cutaneous T-cell Lymphoma; Sezary Syndrome; Mycosis Fungoides |
Merck Sharp & Dohme LLC |
2005-02-03 | PHASE2 |
| NCT00126451 | TERMINATED | Breast Cancer; Colorectal Cancer; Non-small-cell Lung Carcinoma |
Merck Sharp & Dohme LLC |
2004-12-01 | PHASE2 |
| NCT00750178 | COMPLETED | Cancer, Advanced |
Merck Sharp & Dohme LLC |
2004-11-01 | PHASE1 |
| NCT00005634 | COMPLETED | Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Prostate Cancer; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
2000-01 | PHASE1 |
| NCT01039363 | UNKNOWN | Acute Myeloid Leukemia |
Samsung Medical Center |
PHASE2 | |
| NCT01353482 | WITHDRAWN | Malignant Pleural Mesothelioma |
University College, London |
PHASE1; PHASE2 | |
| NCT01386398 | WITHDRAWN | Lymphoma |
European Organisation for Research and Treatment of Cancer - EORTC |
PHASE3 |
(data from https://clinicaltrials.gov, updated on 2026-08-27)
Check the
Vorinostat (SAHA)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Vorinostat (SAHA) Mechanism of Action: HDAC Inhibition in Tumor Cell Research
- Vorinostat (SAHA): Selectivity & Specificity
- Vorinostat (SAHA) Working Concentration | Cell Culture | Treatment
- Vorinostat (SAHA) Solubility in DMSO
- Vorinostat (SAHA) Stock Solution
- Vorinostat (SAHA) Storage
- Vorinostat (SAHA) Stability
- Vorinostat (SAHA) Combination Database
- Vorinostat (SAHA) Molecular Weight
- Vorinostat (SAHA) SMILES
- Vorinostat (SAHA) CAS Number
- Vorinostat (SAHA) Chemical Structure (2D and 3D)
- Vorinostat (SAHA) IC50 for Cell-based and Cell-free Assays
- Vorinostat (SAHA) Sigma (SML0061)? Try a better option.
- Vorinostat (SAHA) MedChemExpress (HY-10221)? Try a better option.
- Vorinostat (SAHA) Cell Signaling Technology (12520)? Try a better option.
- Vorinostat (SAHA) Cayman (10009929)? Try a better option.
- Vorinostat (SAHA) APExBIO (A4084)? Try a better option.
- Vorinostat (SAHA) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.