Cytisine

Catalog No.S2287 Synonyms: Baphitoxine,Sophorine

For research use only.

Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.

Cytisine Chemical Structure

CAS No. 485-35-8

Purity & Quality Control

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Biological Activity

Description Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.
Targets
nAChR [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(199.74 mM)
Water 38 mg/mL
(199.74 mM)
Ethanol 38 mg/mL
(199.74 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 190.24
Formula

C11H14N2O

CAS No. 485-35-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2CNCC1C3=CC=CC(=O)N3C2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04126135 Not yet recruiting Drug: Cytisine|Drug: Nicotine Replacement Therapy (NRT) Nicotine Addiction Loma Linda University|Pfizer|Mongolian National University of Medical Sciences August 2021 Phase 3
NCT03509948 Completed Drug: cytisine Smoking Cessation Achieve Life Sciences April 27 2018 Phase 1
NCT03303911 Terminated Drug: Cytisine Smoking Cessation Achieve Life Sciences October 6 2017 Phase 1|Phase 2
NCT03268343 Completed Drug: Cytisine Smoking Cessation Achieve Life Sciences August 8 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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