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3CAI Akt inhibitor

Cat.No.S6982

3CAI inhibits AKT1 and AKT2.
3CAI Akt inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 193.63

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Chemical Information, Storage & Stability

Molecular Weight 193.63 Formula C10H8ClNO Storage (From the date of receipt)
CAS No. 28755-03-5 Download SDF Storage of Stock Solutions

Mechanism of Action

In vivo
To examine the antitumor activity of 3CAI in vivo, HCT116 cancer cells are injected into the right flank of individual athymic nude mice. Mice are orally administered 3CAI at 20 or 30 mg/kg, I3C at 100 mg/kg, or vehicle 5 times a week for 21 days. Treatment of mice with 30 mg/kg of 3CAI significantly suppresses HCT116 tumor growth by 50% relative to the vehicle-treated group (p<0.05). Remarkably, mice seem to tolerate treatment with these doses of 3CAI without overt signs of toxicity or significant loss of body weight compared with vehicle-treated group. Expression of these AKT-target proteins is strongly suppressed by 30 mg/kg of 3CAI in tumor tissues.
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