CAS No. 4097-22-7

Batch: Purity:99.98
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2',3'-Dideoxyadenosine Chemical Structure
Chemical Structure
Check the 2',3'-Dideoxyadenosine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methanol
CAS Number 4097-22-7
Molecular Formula

C10H13N5O2
Molecular Weight (MW) 235.24
SMILES NC1=C2N=C[N](C3CCC(CO)O3)C2=NC=N1
InChIKey WVXRAFOPTSTNLL-NKWVEPMBSA-N

Biological Activity

2',3'-Dideoxyadenosine (ddA) is a synthetic purine nucleoside reverse transcriptase inhibitor that exhibits potent antiviral activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Following intracellular phosphorylation to its active triphosphate metabolite, ddA selectively incorporates into nascent viral DNA, acting as a chain terminator to disrupt reverse transcription and suppress viral replication and cytopathicity in host cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 47 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 47 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Mitsuya H, et al. Proc Natl Acad Sci U S A. 1986;83(6):1911-5.

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Note: Technical data last updated: Sep 1, 2026.