Home Immunology & Inflammation NOD agonist Inarigivir soproxil

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Inarigivir soproxil NOD agonist

Cat.No.S0349

Inarigivir soproxil (GS 9992, SB 9200) is an oral agonist of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. This compound has broad-spectrum antiviral activity against RNA viruses with EC50 of 2.2 μM and 1.0 μM for HCV 1a and HCV 1b.
Inarigivir soproxil NOD agonist Chemical Structure

Chemical Structure

Molecular Weight: 703.62

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Quality Control

Batch: S034901 DMSO]100 mg/mL]false]Ethanol]60 mg/mL]false]Water]25 mg/mL]false Purity: 99.6%
99.6

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (142.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 60 mg/mL

Water : 25 mg/mL

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 703.62 Formula

C25H34N7O13PS

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 942123-43-5 -- Storage of Stock Solutions

Synonyms GS 9992, SB 9200 SMILES CC(C)OC(=O)OCSP(=O)(OCC1C(CC(O1)N2C=NC3=C(N=CN=C32)N)O)OC4C(OC(C4OC)N5C=CC(=O)NC5=O)CO

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2020-07-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04023721 TERMINATED
Hepatitis B; HBV; Hepatitis B, Chronic
F-star Therapeutics, Inc.
 2019-06-18 PHASE2
NCT04059198 TERMINATED
Hepatitis B; HBV; Hepatitis B, Chronic
F-star Therapeutics, Inc.
 2019-10-10 PHASE2
NCT03434353 TERMINATED
Chronic Hepatitis B
Gilead Sciences
 2018-02-28 PHASE2
NCT03932513 TERMINATED
HBV; Hepatitis B; Hepatitis B, Chronic
F-star Therapeutics, Inc.
 2019-04-11 PHASE2
NCT03493698 COMPLETED
Drug Interaction Potentiation
F-star Therapeutics, Inc.
 2018-05-07 PHASE1
NCT03434353 Terminated
Chronic Hepatitis B
Gilead Sciences|F-star Therapeutics Inc.
 2018-02-28 Phase 2

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