Home Immunology & Inflammation NOD agonist - HCV inhibitor Inarigivir soproxil For research use only.

Inarigivir soproxil

Synonyms: GS 9992, SB 9200

Inarigivir soproxil (GS 9992, SB 9200) is an oral agonist of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. Inarigivir soproxil has broad-spectrum antiviral activity against RNA viruses with EC50 of 2.2 μM and 1.0 μM for HCV 1a and HCV 1b.

Inarigivir soproxil Chemical Structure

Inarigivir soproxil Chemical Structure

CAS: 942123-43-5

Purity & Quality Control

Batch: S034901 DMSO] 100 mg/mL] false] Ethanol] 60 mg/mL] false] Water] 25 mg/mL] false Purity: 99.6%
99.6

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Biological Activity

Description Inarigivir soproxil (GS 9992, SB 9200) is an oral agonist of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. Inarigivir soproxil has broad-spectrum antiviral activity against RNA viruses with EC50 of 2.2 μM and 1.0 μM for HCV 1a and HCV 1b.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03434353 Terminated
Chronic Hepatitis B
Gilead Sciences|F-star Therapeutics Inc.
 February 28 2018 Phase 2
NCT02751996 Completed
Hepatitis B|Hepatitis Viral
F-star Therapeutics Inc.
 May 2016 Phase 2
NCT01803308 Completed
Hepatitis C Infection
Syneos Health|F-star Therapeutics Inc.
 March 2013 Phase 1

Chemical Information & Solubility

Molecular Weight 703.62 Formula

C25H34N7O13PS
CAS No. 942123-43-5 SDF --
Smiles CC(C)OC(=O)OCSP(=O)(OCC1C(CC(O1)N2C=NC3=C(N=CN=C32)N)O)OC4C(OC(C4OC)N5C=CC(=O)NC5=O)CO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (142.12 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 60 mg/mL

Water : 25 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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