Notes: 1:Clickable 2:Unclickable PAMPs TLRs MyD88 IRAK TRAF6 TAB2 TAK1 TAB1 TRAF6 PGN from Gram-negative Bacteria PGN from Gram-negative Bacteria PGN from Gram-positive Bacteria CARD12 CARD12 NOD2 iE-DAP(D-γ-Glu-mDAP) CARD CARDs MDP(MurNAc-L-Ala-D-isoGln) NOD NOD LRRs LRRs RICK RICK RIP2 CARD9 TAKI TAB2 TAB3 MKK3 c-Fos Jun TRAF3 Activation of RICK throughCARD-CARD Interaction K63-linked Ubiquitylation p50 p65 ProteasomalDegradation IRF7 IFN-β JUN AP1-binding Site p50 p65 p65 NF-κB-binding Motif Inflammatory Gene Transcription TBK1 P {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} Ub Ub Ub Ub {{ group.title }} {{ text.text }}