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MLL Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S8934 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
Cell, 2025, S0092-8674(25)01149-3
Nat Cell Biol, 2025, 27(9):1411-1421
bioRxiv, 2025, 2025.05.23.655671
S8996 SNDX-5613 (Revumenib) Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
bioRxiv, 2025, 2025.04.01.646632
Nat Cell Biol, 2024,
Cancers (Basel), 2024, 16(7)1311
E1290 Ziftomenib (KO-539) Ziftomenib (KO-539) is an oral inhibitor of menin targeting the menin–KMT2A protein-protein interaction. It exhibits antileukemic activity and induces apoptosis of acute myeloid leukemia(AML) cells.
E4679 Bleximenib oxalate Bleximenib oxalate(Menin-MLL inhibitor 24 oxalate) is an inhibitor of menin-mixed-lineage leukemia 1 (menin-MLL) . It can be used for the research of cancer.
E1782 DSP5336 DSP5336 is an oral small molecule inhibitor of menin and MLL protein interaction. This compound is undergoing clinical evaluation for its use in the treatment of patients with Relapsed or Refractory Acute Leukemia.
S7265 MM-102 (HMTase Inhibitor IX) MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM.This product may precipitate when dissolved in saline solution or PBS solution. It is recommended to prepare the stock solution in DMSO solution.
Nat Commun, 2025, 16(1):5222
Nat Commun, 2025, 16(1):7483
Cell Rep Med, 2025, 6(2):101928
Verified customer review of MM-102 (HMTase Inhibitor IX)
S7817 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
Cell, 2025, S0092-8674(25)01149-3
Nat Genet, 2025, 57(1):165-179
Front Immunol, 2025, 16:1625673
S7618 MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
ProQuest, 2023, 30484965
Cell Stem Cell, 2022, S1934-5909(22)00417-9
Life Sci Alliance, 2022, 5(4)e202101187
S7619 MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with an IC50 of 648 nM.
Cell Rep, 2025, 44(1):115219
Nat Commun, 2023, 14(1):3062
University of Calgary, 2023,
S7816 MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
Blood Neoplasia, 2025, 2(4):100148
J Clin Invest, 2023, 133(13)e169993
iScience, 2023, 26(10):107726
S7815 MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
Breast Cancer Res, 2022, 24(1):52
Cancer Cell Int, 2022, 22(1):336
J Med Chem, 2020, 31