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Antiviral Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E0153 Lithium Chloride

Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.

Lithium Chloride can be used to induce animal models of Chronic Epilepsy.
Mol Med Rep, 2025, 31(1)30
Mol Med Rep, 2025, 31(4)99
Mil Med Res, 2024, 11(1):27
S6814 GS-441524 GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.
Microbiol Spectr, 2025, 13(4):e0269224
Infect Drug Resist, 2024, 17:531-541
Commun Biol, 2023, 6(1):511
S9063 Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
Cell Death Dis, 2024, 15(8):587
iScience, 2024, 27(10):110862
BioRxiv, 2022, 10.1101/2021.04.12.439420
S8750 NGI-1 NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.
Int J Mol Sci, 2024, 25(5)2768
Cancer Discov, 2023, 13(8):1862-1883
J Cell Biochem, 2022, 10.1002/jcb.30204
S9669 U18666A U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
Int J Mol Sci, 2025, 26(12)5769
Cell Rep, 2024, 43(1):113631
Autophagy Rep, 2024, 3(1)2379193
S5952 Baloxavir marboxil Baloxavir marboxil(S-033188), a cap-endonuclease inhibitor, is an antiviral drug.
Cell Rep Med, 2022, 3(8):100718
bioRxiv, 2020, 2020.08.12.246389
S9303 Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
Phytomedicine, 2019, 67:153163
S2764 DTNB DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. This compound is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.
Acta Biochim Biophys Sin (Shanghai), 2024, 56(9):1311-1322
E0150 Carrageenan

Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. This compound shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.

It can be used to induce animal models of Prostatitis.
E1422 (+)-JNJ-A07 (+)-JNJ-A07 is a highly potent inhibitor of Dengue virus (DENV) with an EC50 of 0.1 nM in the DENV-2 strain (16681) in Vero cells. It exhibits antiviral activity by preventing the formation of the viral replication complex through blocking the interaction between two viral proteins, NS3 and NS4B.
S5554 Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. This compound induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
E0336 CBS1117 CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1), also interferes with the hemagglutinin (HA)-mediated fusion process.
S6867 Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
E0110 Baloxavir Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. This compound inhibits viral RNA transcription via selective inhibition of CEN activity.
S3356 Phosphonoacetic acid

Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. This compound exhibits anti-viral activities.
E0942 BVDV IN-1 BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.
E0066 Theaflavin 3,3'-digallate Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
S0163 Qstatin QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity, which can be a sustainable antivibriosis agent useful in aquacultures.
E0835 CID-1517823 CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM.
S6865 Alisporivir Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
S1102 U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.
Nat Commun, 2025, 16(1):2192
Nat Commun, 2025, 16(1):7156
Adv Sci (Weinh), 2025, 12(44):e11726
Verified customer review of U0126-EtOH
S1623 N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.
Signal Transduct Target Ther, 2025, 10(1):341
J Exp Med, 2025, 222(3)e20241248
Adv Sci (Weinh), 2025, 12(36):e06150
Verified customer review of N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine)
S7775 Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
Nature, 2025, 10.1038/s41586-025-09741-1
Cell, 2025, S0092-8674(25)01233-4
Nat Commun, 2025, 16(1):4945
S1537 Vadimezan (DMXAA) Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. It is also a STING agonist with potential antineoplastic activity, potently inducing IFN-β but relatively low TNF-α expression in vitro. This compound has antiviral activity. Phase 3.
Cell Chem Biol, 2025, 32(2):280-290.e14
Commun Biol, 2025, 8(1):1470
Front Pharmacol, 2025, 16:1528459
Verified customer review of Vadimezan (DMXAA)
S2713 Geldanamycin (NSC 122750) Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.
FEBS J, 2025, 292(11):2823-2842
Cancers (Basel), 2025, 17(8)1341
Nat Commun, 2024, 15(1):9448
Verified customer review of Geldanamycin (NSC 122750)
S2239 Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. This compound reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.
Dev Cell, 2024, S1534-5807(24)00326-5
Cell Mol Life Sci, 2024, 82(1):32
bioRxiv, 2024, 2024.12.01.626286
Verified customer review of Tubacin
S1401 Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
J Biomed Sci, 2024, 31(1):34
Hepatol Commun, 2024, 8(1)e0351
Verified customer review of Tenofovir
S4879 Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
Cancer Discov, 2022, candisc.1117.2021
Cells, 2020, 9(4)E1003
E0365 Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
Signal Transduct Target Ther, 2025, 10(1):171
Int J Biol Macromol, 2024, 276(Pt 1):133792
S9926 ML-SA1

ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. This compound also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of this chemical against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. It induces autophagy. It can be used for the research of broad-spectrum antiviral.
Sci Rep, 2024, 14(1):24836
E0010 Hypocrellin A Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. This compound also is a selective and potent inhibitor of PKC.