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Decarboxylase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S5409 Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
E7388 (S)-2-Allylglycine (S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
Frontiers in Molecular Biosciences, January 12, 2022, 806650
Research Square (Preprint), 2025, nan
Frontiers in Molecular Biosciences, 2022, 806650
E2354 Valepotriate Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.