Home Metabolism Decarboxylase

Decarboxylase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S4582 Eflornithine (DFMO) Hydrochloride Hydrate Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Cancer Lett, 2025, 630:217887
Front Oncol, 2023, 13:1212604
mBio, 2022, 13(5):e0219422
S1891 Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
Drug Design, Development and Therapy, 2026, 1-23
Signal Transduct Target Ther, 2021, 6(1):77
Signal Transduction and Targeted Therapy, 2021, 77
S2453 Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.
Front Pharmacol, 2024, 15:1404532
Viruses, 2024, 16(10)1566
Elife, 2022, 11e72668
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
J Immunother Cancer, 2024, 12(11)e009805
mBio, 2022, e02177-21
Scientific Reports, 2017, 8491
E8286New Ivospemin Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
S3086 Maleic acid

Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. This compound affects the extracellular GABA levels.
E0654 D-Arginine D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448 S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189 TES-1025 TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444 4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5409 Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
E7388 (S)-2-Allylglycine (S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
Research Square (Preprint), 2025, nan
Frontiers in Molecular Biosciences, 2022, 806650
The FASEB Journal, 2022, e22229
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.