Home GPCR & G Protein PAR activator Trypsin

research use only

Trypsin PAR activator

Cat.No.E4452

Trypsin(Cocoonase) is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. It activates PAR2 and PAR4 and induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. It also promotes cell proliferation and differentiation and can be used in the research of wound healing and neurogenic inflammation.
Trypsin PAR activator Chemical Structure

Chemical Structure

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight Formula Storage (From the date of receipt)
CAS No. 9002-07-7 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
PAR2
PAR4
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05485155 Recruiting
Eosinophilic Esophagitis
Children''s Hospital Medical Center Cincinnati|CSL Behring|National Institutes of Health (NIH)
 March 1 2024 Phase 2
NCT05802667 Not yet recruiting
Inflammation|Acute ST Segment Elevation Myocardial Infarction|Prognosis
Peking University Third Hospital
 April 1 2023 --
NCT05622838 Not yet recruiting
alpha1 Anti-trypsin|Pre-Eclampsia|Intrauterine Growth Restriction
Assiut University
 December 2022 --
NCT05474664 Not yet recruiting
Fontan Operation|Protein-Losing Enteropathy|Camostat Mesylate
Seoul National University Hospital
 August 1 2022 Phase 2
NCT05037461 Recruiting
Neuroendocrine Tumor of Pancreas|Multiple Endocrine Neoplasia Type 1
J.M. de Laat|Radboud University Medical Center|Erasmus Medical Center|Maastricht University Medical Center|Leiden University Medical Center|University Medical Center Groningen|UMC Utrecht
 May 1 2022 Not Applicable
NCT05083637 Completed
Malnutrition
International Centre for Diarrhoeal Disease Research Bangladesh
 October 19 2021 Not Applicable

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