Home GPCR & G Protein PAR antagonist Atopaxar

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Atopaxar PAR antagonist

Cat.No.S0342

Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist.
Atopaxar PAR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 527.63

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Quality Control

Batch: S034201 Ethanol]100 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.14%
99.14

Solubility

In vitro
Batch:

Ethanol : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 527.63 Formula

C29H38FN3O5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 751475-53-3 -- Storage of Stock Solutions

Synonyms E5555, ER-172594-00 Smiles CCOC1=C(C(=C2C(=C1)CN(C2=N)CC(=O)C3=CC(=C(C(=C3)N4CCOCC4)OC)C(C)(C)C)F)OCC

Mechanism of Action

Targets/IC50/Ki
PAR-1
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01241669 Completed
Healthy Subjects
Eisai Inc.
 October 2010 Phase 1

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