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Sulfathiazole

Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.

Sulfathiazole Chemical Structure

Sulfathiazole Chemical Structure

CAS: 72-14-0

Purity & Quality Control

Batch: S311601 DMSO] 51 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.80%
99.80

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Biological Activity

Description Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
In vitro
In vitro Sulfathiazole (20 μg/L) starts to be degraded between day 31 and day 38 in one of the two batch reactors containing different wastewater matrices. Sulfathiazole is degraded at a substantially faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level. [2] Sulfathiazole sorption to inorganic sorbents exhibits pronounced pH dependence consistent with sorbate speciation and sorbent charge properties. Sulfathiazole cations are most important for sorption to clay minerals, followed by neutral species. [3] Sulfathiazole posseses at least five crystalline or polymorphic forms: I, II, III, IV and V. Although both amido and imido forms are possible for the sulfathiazole molecule, the Sulfathiazole exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) causes a significant increase in reactive oxygen species (ROS) generation and lipid peroxidation in the presence of ultraviolet B (UV-B) light. Exposure to Sulfathiazole and UV-B light causes apparent up-regulation of alpha-esterase, hemoglobin, and vitellogenin mRNA and significantly affect the survival of daphnids. [5]

Chemical Information & Solubility

Molecular Weight 255.32 Formula

C9H9N3O2S2
CAS No. 72-14-0 SDF Download Sulfathiazole SDF
Smiles C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (199.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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