Home Microbiology Anti-infection chemical Sulfamethoxypyridazine

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Sulfamethoxypyridazine Anti-infection chemical

Cat.No.S4250

Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
Sulfamethoxypyridazine Anti-infection chemical Chemical Structure

Chemical Structure

Molecular Weight: 280.3

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S425001 DMSO]56 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

Chemical Information, Storage & Stability

Molecular Weight 280.3 Formula

C11H12N4O3S

 Storage (From the date of receipt)
CAS No. 80-35-3 Download SDF Storage of Stock Solutions

Synonyms CL 13494 Smiles COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N

Solubility

In vitro
Batch:

DMSO : 56 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo
Sulfamethoxypyridazine is found to be highly effective in a preliminary study of P. carinii-infected rats. This compound is also found to be as effective as sulfamethoxazole in P. carinii-infected rats at 1 mg/kg of body weight/day. It is effective aganist a murine model of P. carinii with ED50s of 0.06 mg/kg/day and 0.08 mg/kg/day as determined by the Giemsa and silver stain scores, respectively. This chemical at either 0.1 mg/kg/day or 0.3 mg/kg/day is found to be significantly more effective than sulfamethoxazole at 0.47 mg/kg/day) aganist a murine model of P. carinii. [1] It exhibits the biological half lives of 11.0 hours and 13.7 hours following im and sc administration, respectively, in goats. The compound exhibits the systemic availabilities of 68.6% and 58.7% following im and sc administration, respectively, in goats. [2] It exhibits the distribution and elimination half life of 0.1 hour and 6.28 hours, respectively, in goats. This drug exhibits the values of apparent volume of distribution at steady state and total body clearance of 0.39 mL/kg/min and 0.73 mL/kg/min, respectively, in goats. [3]
References

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