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(R)-Serine NMDAR agonist

Cat.No.S6224

(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. This compound acts as obligatory coagonist at the glycine site associated with the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) and has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
(R)-Serine NMDAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 105.09

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Quality Control

Batch: Purity: 99.57%
99.57

Solubility

In vitro
Batch:

Water : 21 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 105.09 Formula

C3H7NO3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 312-84-5 -- Storage of Stock Solutions

Synonyms N/A Smiles C(C(C(=O)O)N)O

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03359785 Completed
Schizophrenia
Neurocrine Biosciences|Takeda
 January 10 2018 Phase 2
NCT02716987 Completed
Healthy
Neurocrine Biosciences|Takeda
 March 21 2016 Phase 1
NCT01018056 Completed
Tourette Syndrome
Johns Hopkins University|National Institute of Mental Health (NIMH)
 November 2009 Phase 4
NCT00789022 Unknown status
Schizophrenia|Schizophreniform|Schizoaffective Disorder|Brief Psychotic Episode
Shalvata Mental Health Center
 January 2009 --

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