0
United States ( Change Country )

PF-3845

Catalog No.S2666
Price Stock Quantity
$ 120
$ 470
$ 1270
 
processing...
You can order by phone, email or fax

Tel: +1-832-582-8158    Fax: +1-832-582-8590
Email: sales@selleckchem.com

Free Overnight Delivery on all orders over $ 500.

Order PF-3845 now
and get it on .

PF-3845 Chemical Structure

Recommended Products

  • [Ala92]-p16 (84-103)

    [Ala92]-p16 (84-103) is a CDK inhibitor with IC50 of 1.5μM for cyclin-dependent kinase-4 (cdk4)/cyclin D1

  • Bax inhibitor peptide,negative control

    Bax inhibitor peptide,negative control is a negative control peptide for the Bax inhibitor peptides V5 and P5.

  • JIP-1(153-163)

    JNK and p38 MAPK inhibitor

  • STF-62247

    Targeting VHL-deficient RCC cells, in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 μM).

  • BTZ043 racemate

    BTZ043 racemate is a decaprenylphosphoryl-b-D-ribose 2’-epimerase inhibitor with MIC of 2.3 and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

  • GSK690693

    GSK690693 is a pan-Akt kinase inhibitor,IC50 of Akt 1, 2, and 3 at 2, 13, and 9 nM respectively.

  • Odanacatib (MK 0822)

    cathepsin K inhibitor with an IC50 of 0.2nM.

  • Malotilate

    Malotilate is a liver protein metabolism improved compound.

  • PA-824

    PA-824 is an experimental anti-tuberculosis drug with MIC of less than 1 μg/mL for tuberculosis.

Biological Activity

 

PF-3845 is a potent, selective, and irreversible fatty acid amide hydrolase (FAAH) inhibitor with a Ki of 0.23 μM. [1] Fatty acid amide hydrolase (FAAH) is an enzyme that catalyzes N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). Mechanistic and structural studies demonstrated that PF-3845 acts as a covalent inhibitor and carbamylates the active site serine241 of FAAH. PF-3845 covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment. Initial experiments indicated that PF-3845 is 10 to 20 times more potent than other FAAH inhibitors and has superior pharmacokinetic properties. PF-3845 significantly and persistently blockes inflammatory pain in rats through a cannabinoid receptor-dependent mechanism. In animal studies, PF-3845 elevated brain anandamide levels for up to 24 hours and produced a marked cannabinoid receptor-dependent reduction in inflammatory pain. [2]

References on PF-3845
  • [1] Chem Biol. 2009 Apr 24;16(4):411-20.
  • [2] Br J Pharmacol. 2011 Apr 20.;
Molecular Weight (WM): 456.46
Formula:

C24H23F3N4O2

CAS No.: 1196109-52-0
Synonyms:
N/A
Dissolve in (25°C): DMSO ≥91mg/mL 
Water <1mg/mL 
Ethanol ≥91mg/mL 
Storage: 2 years-20°CPowder
1 week-4°Cin DMSO
1 month-80°in DMSO

Quality Control & MSDS

View current batch:
COA H-NMR HPLC COA H-NMR HPLC

Research Area

Related Inhibitors

Recommended Screening Libraries

Our scientific support team are available to answer any questions or queries.
Fill out an inquiry form for PF-3845 for help.

Free Sample and Reward

We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) > See Details

Recently Viewed Items

Keywords:buy PF-3845 | PF-3845 supplier | purchase PF-3845 | PF-3845 cost | PF-3845 manufacturer | order PF-3845 | PF-3845 distributor