JZL195

Catalog No.S6609 Batch:S660901

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Technical Data

Formula

C24H23N3O5

Molecular Weight 433.46 CAS No. 1210004-12-8
Solubility (25°C)* In vitro DMSO 43 mg/mL (99.2 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
Targets
FAAH [2] MAGL [2]
2 nM 4 nM
In vivo

Systemic administration of JZL195 reduces horizontal and vertical motor activity dose-dependently, and increases time spent in immobility. JZL195 produces a pronounced 2-AG elevation at all doses, and increases brain AEA and OEA levels due to its inhibitory activity at FAAH[1].

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Male Wistar rats

  • Dosages

    5, 15 and 30 mg/kg

  • Administration

    i.p.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.